Protein
Olfactomedin-like protein 3B
Function
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity).
Similarity
Belongs to the OLFML3 family.
Sequence
MKATIFFLLLTVLAHSRSQYHYQGLMNYLENRMLAMEERIALWHEQNNRYNSDLKEFRQQAADLLEKLSKDHSKLRSDLEGAGARVDRVEREMDYIETKNPPKPCVKAADKMVEQDAVIKEKKKEEFFELSVCVNIISSLKAMKILKRLGSPKGLWTKDARSAKIYVFNGTSDNTLYEFSSMRELSSSSGVSKGKQITVPTAWNGTGHAVYDGFLYYISESSELQVVKYDLTNSSVADTAVLPMEERSPVYQLNPETLVDLVADEDGLWALYPAGDTINLAKMDSNSLDIEQMWDTACPRSNAEAAFIVCGTVYVVYNTKPPSRSRVQCVFDVNDMVSNGEAPLIYFPRRYGAHSSLKYNPEERQLYAWDDGYQILYKLELKKKLWAVMPPPEE