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oleS

Gene
oleS
Protein
Glucose-1-phosphate thymidylyltransferase
Organism
Streptomyces antibioticus
Length
356 amino acids
Function
Involved in the biosynthesis of the two 2,6-deoxysugars, dTDP-L-oleandrose and dTDP-D-desosamine, attached to the macrolactone ring oleandolide to produce the aglycone antibiotic oleandomycin (PubMed:10770761). Catalyzes the formation of dTDP-glucose from deoxythymidine triphosphate (dTTP) and glucose 1-phosphate (By similarity).
Similarity
Belongs to the glucose-1-phosphate thymidylyltransferase family.
Mass
38.142 kDa
Sequence
MKALVLAGGSGTRLRPITHTSAKQLVAVANKPVLFYGLEAIAAAGITDVGLIVGDTAGEVPRAVGDGAKFGLDITYIEQSRPLGLAHAVLIAHTYLGDDDFVMYLGDNFIVGGIDDLVRTFRDGRRPAARILLTHVSDPSGFGVAELDDDGRVVGLEEKPRHPKSDLALVGVYFFTPAIHEAVRAIEPSWRGELEITHAIQHLIDNGADIQSMVIEGYWKDTGNVADMLEVNRTVLEDLEPRIEGTVDEHTVVIGRVVVGEGARVTNSRIMGPAIIGAGPEISDSYIGPFTSVGDNCRITGSEMEFSIMLAESAITGVRRIEGSLIGRNVQVTQSLHAPNAHRFVLGDHSKVEIQS