oleD

Oleandomycin glycosyltransferase

430 amino acids

Specifically inactivates oleandomycin via 2'-O-glycosylation using UDP-glucose.

Belongs to the UDP-glycosyltransferase family.

47.136 kDa

MTTQTTPAHIAMFSIAAHGHVNPSLEVIRELVARGHRVTYAIPPVFADKVAATGPRPVLYHSTLPGPDADPEAWGSTLLDNRRTFLNDAIQALPQLADAYADDIPDLVLHDITSYPARVLARRWGVPAVSLSPNLVAWKGYEEEVAEPMWREPRQTERGRAYYARFEAWLKENGITEHPDTFASHPPRSLVLIPKALQPHADRVDEDVYTFVGACQGDRAEEGGWQRPAGAEKVVLVSLGSAFTKQPAFYRECVRAFGNLPGWHLVLQIGRKVTPAELGELPDNVEVHDWVPQLAILRQADLFVTHAGAGGSQEGLATATPMIAVPQAVDQFGNADMLQGLGVARKLATEEATADLLRETALALVDDPEVARRLRRIQAEMAQEGGTRRAADLIEAELPARHERQEPVGDRPNVGDRPAGVRSDRQRSAL

oleD

2-alkyl-3-oxoalkanoate reductase

387 amino acids

Involved in olefin biosynthesis (PubMed:20418444). Catalyzes the reversible stereospecific NADPH-dependent reduction of 2-alkyl-3-oxoalkanoic acids to 2-alkyl-3-hydroxyalkanoic acids (By similarity). The S.oneidensis oleABCD genes produce 3,6,9,12,15,19,22,25,28-hentriacontanonaene, which may aid the cells in adapting to a sudden drop in temperature (PubMed:20418444).

Belongs to the 3-beta-HSD family.

41.885 kDa

MTDNSSISLTPADLEHVPLQPTRLKQVGGDQACIKLSLDAREQTALDALAAKVSHAFVTGAGGFLGKAICQRLIAAGIKVTGFARGRYLELEALGVTMVQGDLVNPEQVKQAMQGCDIVFHVASKAGVWGDRDSYFCPNVKGAANVIAACKALKINKLVYTSTPSVTFAGEDESGINESTPYASRFLNYYAHSKAIAEKMMLDANQSSSTNAAYVLKTVALRPHLIWGPNDPHLVPRVLARGRLGKLKLVGREDKLVDTIYIDNAAYAHVLAALELCQATPKCQGKAYFISNDEPVTMAKMLNMILACDGLPPVTQRVPQMLAYAVGAVLETAYRLLNKQEEPIMTRFVAKQLSCSHYFDISAAKQDFGYSALVSIEEGMKRLKASL

oleD

2-alkyl-3-oxoalkanoate reductase

337 amino acids

Involved in olefin biosynthesis (PubMed:21266575, PubMed:28223313). Catalyzes the reversible stereospecific NADPH-dependent reduction of 2-alkyl-3-oxoalkanoic acids to 2-alkyl-3-hydroxyalkanoic acids (By similarity).

Belongs to the 3-beta-HSD family.

36.252 kDa

MMKILVTGGGGFLGQALCRGLVARGHEVVSFQRGDYPVLHTLGVGQIRGDLADPQAVRHALAGIDAVFHNAAKAGAWGSYDSYHQANVVGTQNVLDACRANGVPRLIYTSTPSVTHRATNPVEGLGADEVPYGEDLRAPYAATKAIAERAVLAANDAQLATVALRPRLIWGPGDNHLLPRLAARARAGRLRMVGDGSNLVDSTYIDNAAQAHFDAFAHLAPGAACAGKAYFISNGEPLPMRELLNRLLAAVDAPAVTRSLSFKTAYRIGAVCETLWPLLRLPGEVPLTRFLVEQLCTPHWYSMEPARRDFGYVPQISIEEGLQRLRSSSSRDISITR

oleD

2-alkyl-3-oxoalkanoate reductase

330 amino acids

Involved in olefin biosynthesis. Catalyzes the reversible stereospecific NADPH-dependent reduction of 2-alkyl-3-oxoalkanoic acids to 2-alkyl-3-hydroxyalkanoic acids. In the oxidative direction, syn-2-decyl-3-hydroxytetradecanoic acid is the preferred substrate. In the reductive direction, (2R/S)-2-hexyl-3-ketodecanoic acid is accepted as substrate.

Belongs to the 3-beta-HSD family.

35.48 kDa

MKILVTGGGGFLGQALCRGLVERGHQVLAFNRSHYPELQVMGVGQIRGDLADPQAVLHAVAGVDAVFHNGAKAGAWGSYDSYHQANVIGTDNVIAACRAHGIGRLVYTSTPSVTHRATHPVEGLGADEVPYGEDFQAPYAATKAIAEQRVLAANDASLATVALRPRLIWGPGDQQLVPRLAERARQGRLRLVGDGSNKVDTTYIDNAALAHFLAFEALAPGAACAGKAYFISNGEPLPMRELVNQLLAAVGAPRVDKAISFKTAYRIGAICERLWPLLRLRGEPPLTRFLAEQLCTPHWYSMEPARRDFGYVPQVSIEEGLRRLKASSAA