Protein
Probable ornithine decarboxylase
Organism
Dictyostelium discoideum
Function
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Similarity
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Sequence
MTGTKRNGEEVVNENNNNNVAEETNKKAKVDESSTETTESTSCSLLSRCEKLDIVRKELDVKPWDQGKVTIQELITSLLDKTDRDAFFVADVGVIIKQWQKWVKNLPNVKPYYAVKCNPTVGVLRVLDALGTNYDCASRTEIESVLNLGVDPSRIIYANPCKQISALKFARAHNVKLMTFDNLSELEKIEKFFPEAELVLRIAPDDSKSVMRFGSKFGVHIDDCNDLLEMAKEMNLKVVGVSFHVGSGCQSGDSYADALIMVKSVFDMAKKLNMELTLVDVGGGFTGSDDEKFNAFTKVIREKTAELFSPNVKIIAEPGRYFAAQSHTLAVTVISKRSIKQEDNRQHPRRTSNNMRQYNYYLADGVYGSFNNTKFDYAKVEPLLLKPSTKQPTPCTLFGPTCDSIDVVLKDTQIPELKIGDWLYFQDMGAYTIASSSSFNGFCPPPVYYYNSIPEEELKNL