Protein
NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.
Similarity
Belongs to the complex I 75 kDa subunit family.
Sequence
MLRSTLSRSAWRTGRHQAARNASRAFSATAQRPAEVELTIDGKKVSIEAGSALIQACEKAGVTIPRYCYHEKLMIAGNCRMCLVEVEKVPKPVASCAWPVQPGMVVKTNSPLTHKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGGDRGRFHEVGGKRAVEDKNMGPLIKTSMNRCIQCTRCVRFANDIAGAPELGSTGRGNDLQIGTYLEKNLDSELSGNVIDLCPVGALTSKPYAFRARPWELKKTESIDVLDGLGSNIRVDTRGLEVMRILPRLNDEVNEEWINDKTRFACDGLKTQRLTIPLVRREGKFEPASWDQALTEIAHAYQTLNPQGNEFKAIAGQLTEVESLVAMKDLANRLGSENLALDMPSGHKPLAHGVDVRSNYIFNSSIVGIESADVILLVGTNPRHEAAVLNARIRKQWLRSDLEIGVVGQTWDSTFEFEHLGTDHAALQKALEGDFGKKLQSAKNPMIIVGSGVTDHGDANAFYETVGKFVDSNASNFLTEEWNGYNVLQRAASRVGAFEVGFTVPSAEIAQTKPKFVWLLGADEFNEADIPKDAFIVYQGHHGDRGAQIADIVLPGAAYTEKAGTYVNTEGRVQMTRAATGLPGAARTDWKILRAVSEYLGVRLPYDDVAQLRDRMVEISPALSSYDIIEPPSLQQLSKVQLVEQNQGATATNEPLKKVIENFYFTDAISRSSPTMARCSAAKKTGDPRTNFMAPGMEEDRPMGQIAYGA