Protein
Non-toxic nonhemagglutinin type D
Organism
Clostridium botulinum D phage
Function
Assembles with botulinum neurotoxin type D (BoNT/D) and protects it against pH-mediated inactivation or protease activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not at pH 6.0. The non-toxic component is necessary to maintain toxicity.
Similarity
Belongs to the botulism non-toxic nonhemagglutinin family.
Sequence
MDINDDLNINSPVDNKNVVIVRARKTNTFFKAFKVAPNIWVAPERYYGEPLDIAEEYKLDGGIYDSNFLSQDSERENFLQAIITLLKRINNTISGKQLLSLISTAIPFPYGYVGGGYSSPNIFTFGKTPKSNKKLNSLVTSTIPFPFGGYRETNYIESQNNKNFYASNIVIFGPGSNIVENNVICYKKNDAENGMGTMAEILFQPLLTYKYNKFYIDPAMELTKCLIKSLYFLYGIKPSDDLVVPYRLRTELDNKQFSQLNIIDLLISGGVDLEFINTNPYWFTNSYFSNSIKMFEKYKNIYETEIEGNNAIGNDIKLRLKQKFQNSVQDIWNLNLNYFSKEFNSIIPDRFSNALKHFYRKQYYTMDYGDNYNINGFVNGQINTKLPLSDKNTNIISKPEKVVNLVNANNISLMKSNIYGDGLKGTTEDFYSTYKIPYNEEYEYRFNDSDNFPLNNISIEEVDSIPEIIDINPYKDNSDDLLFTQITSTTEEVITHTALPVNYLQAQIITNENFTLSSDFSKVVSSKDKSLVYSFLDNLMSYLETIKNDGPIDTDKKYYLWLKEVFKNYSFDINLTQEIDSSCGINEVVIWFGKALNILNTSNSFVEEYQNSGPISLISKKDNLSEPNIEIDDIPDSLLGLSFKDLNNKLYEIYSKNRVYFRKIYFNFLDQWWTEYYSQYFELICMAKQSILAQESVVKQIIQNKFTDLSKASIPPDTLKLIKETTEKTFIDLSNESQISMNRVDNFLNKASICVFVEDIYPKFISYMEKYINNINIKTREFIQRCTNINDNEKSILINSYTFKTIDFKFLNIQAIKNFFNSQVEQVMKEMLSPYQLLLFATRGPNSNIIEDISGKNTLIQYTESVELVYGVNGESLYLKSPNETVEFSNNFFTNGLTNNFTICFWLRFTGKDDDKTRLIGNKVNNCGWEIYFEDNGLVFEIIDSNGNQESVYLSNVINNNWYYISISVDRLKDQLLIFINDKNVANVSIEQILNIYSTNVISLVNKNNSIYVEELSVLDKPVASEEVIRNYFSYLDNSYIRDSSKSLLEYNKNYQLYNYVFPETSLYEVNDNNKSYLSLKNTDGINIPSVKFKLINIDESKGYVQKWDECIICVSDGTEKYLDISPENNRIQLVSSKDNAKKITVNTDLFRPDCITFSYNDKYFSLSLRDGDYNWMICNDNNKVPKGAHLWILKS