Protein
2-hydroxychromene-2-carboxylate isomerase
Organism
Sphingobium xenophagum
Function
Involved in the naphthalene and naphthalenesulfonate catabolic pathway. Catalyzes the reversible glutathione-dependent isomerization of 2-hydroxychromene-2-carboxylate (HCCA) to trans-O-hydroxybenzylidenepyruvate (THBPA). It can also use 2-hydroxybenzo[g]chromene-2-carboxylate as substrate.
Similarity
Belongs to the GST superfamily. NadH family.
Sequence
MTKTIDFYFDFISPFSYLAQVKLPDLARRTGCVIEYRPIDIPEAKIAAGNYGPSNREVVPKIKVMMADLERWAAKYEVPLTFPASFACSDWNCAALYARGQDQAEAFVTAAYHRIWGIGIDPRDQNELRGCAEDVGLDADALCEFVRSPAGQGEYRKARTQAYQRGVFGAPMMFVDDQIFWGNDRLDFLESYLLD