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nrnA

Gene
nrnA
Protein
Bifunctional oligoribonuclease and PAP phosphatase NrnA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
336 amino acids
Function
Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities. Degrades RNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 2-mers. Also degrades 24-mers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.
Similarity
Belongs to the NrnA oligoribonuclease family.
Mass
35.415 kDa
Sequence
MTTIDPRSELVDGRRRAGARVDAVGAAALLSAAARVGVVCHVHPDADTIGAGLALALVLDGCGKRVEVSFAAPATLPESLRSLPGCHLLVRPEVMRRDVDLVVTVDIPSVDRLGALGDLTDSGRELLVIDHHASNDLFGTANFIDPSADSTTTMVAEILDAWGKPIDPRVAHCIYAGLATDTGSFRWASVRGYRLAARLVEIGVDNATVSRTLMDSHPFTWLPLLSRVLGSAQLVSEAVGGRGLVYVVVDNREWVAARSEEVESIVDIVRTTQQAEVAAVFKEVEPHRWSVSMRAKTVNLAAVASGFGGGGHRLAAGYTTTGSIDDAVASLRAALG

Gene
nrnA
Protein
Bifunctional oligoribonuclease and PAP phosphatase NrnA
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Length
324 amino acids
Function
Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities. Degrades RNA and DNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for longer oligomers. Also degrades 11- and 24-mers, but less efficiently. Directionality is controversial; shown to degrade 5-mers and less in a 3' to 5' direction (PubMed:22114320), and 11-mers in a 5' to 3' direction (PubMed:21087930). Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.
Similarity
Belongs to the NrnA oligoribonuclease family.
Mass
37.145 kDa
Sequence
MNSQVHRKGSIAEAVSAIQAHDKIVIFHHIRPDGDCLGAQHGLARLIQTNFPHKQVFCVGDPKHNFPWLEMVFTPKEQITPELMQQALAVIVDANYKERIECRDLLDQNQFKAVLRIDHHPNEDDLNTTHNFVDASYIAAAEQVVDLAVQAKWKLSPPAATALYLGIYTDSNRFLYSNTSWRTLYLGSMLYRAQANIAKIHDELNHTSLKDIQFKQYVFKNFQTFQNVIYFVADKKFQKKLKVTPLECARVNILANIEQFHIWLFFIEEGKNHYRVEFRSNGINVREVALKYGGGGHIQASGAVLKSKRDIIRVVQDCQKQIAV

Gene
nrnA
Protein
Bifunctional oligoribonuclease and PAP phosphatase NrnA
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length
324 amino acids
Function
Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities. Degrades short RNA and DNA oligonucleotides with a length of up to 33 nucleotides, although the enzyme is most active on shorter substrates, in a 5' to 3' direction. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP, has very low activity on cAMP and cGMP.
Similarity
Belongs to the NrnA oligoribonuclease family.
Mass
35.121 kDa
Sequence
MDGNAPEPRYWEKMRLVAEVLKAVEGPIYIATHVDPDGDAIGSSLGLYRALKALGKEAYWVADPPRFLRFLPKEEEYSDPVEKLPPGATLVALDSAEPSRVVGVPVEGFVINIDHHGTNPRFGHLHVVDPSKAATAQMVKDLIDLLGVEWTAEIATPVLTGILTDTGNFRFANTTPEVLRVAAELLGYGVKLAELTDRLQFRPPSYFRLMGQVLSTVAFHFGGLLVTAHLPEDAGAEEDSDDFVGLIRYVEGSVVSVFLRKREEGVKVSIRSRGGVSAQNIALKLGGGGHVPAAGATLKGLDLDQAYERVLEAVREELTRAGYL

Gene
nrnA
Protein
Bifunctional oligoribonuclease and PAP phosphatase NrnA
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Length
318 amino acids
Function
Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities. Degrades RNA and DNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for longer oligomers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP (By similarity).
Similarity
Belongs to the NrnA oligoribonuclease family.
Mass
36.413 kDa
Sequence
MKKGSITEAINAIKQFDKIVIFHHVRPDGDCLGAQQGLFHLIKANFKNKEVKCVGNNNNLFSFINMTFTNQIDESFLKEALAIVVDANYKNRIELRELLDKNLFKAVLRIDHHPNEDDLNTSFNFVEESYVACCEQIVEMATVAKWTIPPVAATLLYIGIYTDSNRFLYSNTSYRTLYLAAILYKAKADIRIVHDHLNHTSLADLKFKKYVYNHFKTQGQVIYFICTKKIQKRLRMTADQCARVNLLSNIADYKIWLFFIEQANNEIRIELRSNGINVRDIAIKYGGGGHNNASGAIITNKKQISDVVSDCVKKIVYN

Gene
nrnA
Protein
Bifunctional oligoribonuclease and PAP phosphatase NrnA
Organism
Bacillus subtilis (strain 168)
Length
313 amino acids
Function
Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities. Degrades RNA and DNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 3-mers. Directionality is controversial; shown to degrade 5-mers and less in a 3' to 5' direction (PubMed:17586819), and 11-mers in a 5' to 3' direction (PubMed:21087930). Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.
Similarity
Belongs to the NrnA oligoribonuclease family.
Mass
35.084 kDa
Sequence
MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPEKNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKIDHHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRFLFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASVFIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLARKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE

Gene
nrnA
Protein
Probable bifunctional oligoribonuclease and PAP phosphatase NrnA
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Length
310 amino acids
Function
Probable bifunctional enzyme which has pAp-phosphatase and may have oligoribonuclease activities. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. Complementation studies suggest it also has RNA oligoribonuclease activity, although this has not been shown in vitro using 5- or 20-mers. Involved in superoxide stress response and sulfur assimilation.
Similarity
Belongs to the NrnA oligoribonuclease family.
Mass
34.625 kDa
Sequence
MTAFKTILAKIKAYDTIIIHRHMKPDPDALGSQVGLKEMITSNFPQKTVKVTGYNEPSLSWLAQMDDVSDKDYEGALVIVVDTANRPRIDDQRYLNGNFLIKIDHHPDEDHYGDLSYVDTKASSASEIITDFALQNQLKLSDQAARLLYAGILGDTGRFLYPATTSKTFIIASELLKYDFDFAALARQMDSFPYKIAKLQAYVFENLEIDKNGAARIILSQKILKKFNLTDAETSAIVSSPGKIDTVQVWAIFVEQADGHYRVRLRSKSTVINEVAKRHAGGGHPLASGANSYSLAENEDIYQELKNLLK