nrde-2

Nuclear RNAi defective-2 protein

1270 amino acids

Involved in short interfering RNAs-mediated silencing in nuclei (PubMed:20543824). Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerase II during the elongation phase of transcription (PubMed:20543824). Required for exogenous RNAi-induced H3K27 methylation (PubMed:26365259).

Belongs to the NRDE2 family.

147.636 kDa

MFRAYGNNGLKNPERISGENPDLYTQTRAAVQQRATTTLKRNEKQKLAVQNDSVFQQVGIGESDSDDDNGGVRIRMSPHRYIDPDDVFTLPEVKKQNALRDAKIAARAAQATAYNTFPSVKSLNGCQDPPETSQQSTSRKRSASNSRSPSRSHSRRYDRDNGRQRSRSREKKRRKKERRRKRSSSRSSSSSRSRDRSSRARDTSSHTLMKMNKPAKYAFLTDEEYRTCDAYISSAFITQTKSDCENYTQGVPKKEIAKCRLSVKFIVGLEHNNILFNNIYGAEYARDKENRPFWEQLDRYLKDVPKETFFRYVPPVGGYWKIRDRVDLLNLDHIDDDVLANDSDNRKDAFTFELEQAKKTFSENVHNIDALIKVISMEEEMCRRNVGSFSSSNPAALAERHQEMVKKAIKADGRNAKLRLMKIELLIKMDPNSPTIIDDFKNLTITFPHEPMVWIKYLDYIQYDSNVYNYKKLKNAFEDCIRQVTGLTNGTLLSHLNAVNDRPLLRMFHLWIYIRYLKWMISCAHTPVVLANIQATFEYNFGLADVEKRTSTNSKEREVRLEEFWESGLPRIGDEGAVGAEKMLKQSEELSDEDIQKLENDDFDILISRTEETIATCLQAQRDVQISWIEVEREMMNIDARVKRTKLKDCELYEDHVDDLETCELWDIIPFDRIRYYEAPGDCANFDFVQPFLELLGVKFLNSTNCFTTTEQIISDWISNDSTVNFYKTPTYTEKKCFEVGNNILKFMLYNRLKLTENNPEYLDKTMVKYLLAMLVTEASEQEKKLNFHSFKLNLKNLVGTFITKHPDIFKRAMLSKITGIVYMEKFVSWWERALKEQEKVVEADERRKNYKEIKMEEGVVDDVKFDVILLKKDKERVQTIRDKIRDMIDIAIPKSTEKLIQSADSSLPTLQLHLYANVLRGRLSILNQNALEETRDVFCKEILGIHTSEFESDEALLLALDQGLNELLEHCKEKDNLESVDSIPELPRAEALCEALKVVAVFVFLDKMAFSRRAVDCLIANAITKFEQFEAKKNDFNRGTYEKYCDQIDLKFITDTLITFFSHKKHRFIYNENFKKLIFQASQAFPCDSKYAKMLGELHSSGRLQVMKLQGFTDSRNSILNAKRDQQFDPELETRLLMNSLTIMFSWMNAANRIGDAGNQILYKNWKREAANTRDPAIWRQVIRVASKLSQKILKDDAYTRARGQCTWALNLHFDYIEAKTVRKNGDLMEMIYLILEQSMGQEHSLFVTDEEYMKTQQEIGLQYSESGR