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nprt-1

Gene
nprt-1
Protein
Nicotinate phosphoribosyltransferase
Organism
Caenorhabditis elegans
Length
562 amino acids
Function
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
Similarity
Belongs to the NAPRTase family.
Mass
63.347 kDa
Sequence
MSFILPSESIDGTHPCNGLHMNGQDSLVQPLLTDFYQITMCYAYWKTGTHNEPAVFDVFFRKNPFQGEFTVFAGLEDCLRFVENFKFSQSDIDYVKKILPENAEPEFYEYLETLNGSHLTIEAVAEGSVVFPKVPLLTINGPLAMCQLIETSILNLVNYASLVATNAARFRQASGWKIQLLEFGLRRAQGPNGGLTASKYCYIGGFDATSNVLAGKLYGIPVKGTQAHSFICSFSSPAELKVRLLNHKITNEKADLFQISMEKRAWLLDQFSWKAALSEVSDGELSAFVAYAIAFPDTFLALIDTYDVIRSGVVNFVAVSLALHDLGYRSMGCRIDSGDLSYLSKELRECFVKVSTLKGEYKFFEKMSIVASNDINEETIMSLNDQQHEINAFGVGTHLVTCQKQPALGCVYKLVAQSAQPKIKLSQDVTKITIPGKKKCYRIFGKNGYAILDLMMLEDEPEPQPNQQILCRHPFEESKRALVNANKIIKLHNVYWKDGEMITPLPTLNEIKEHVNESIRSTLRQDHRRYLNPTPYKVSVSERLYQFLHTLWLQNAPIGQLE