npc-1

Nascent polypeptide-associated complex subunit alpha

200 amino acids

Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Npc-1/egd2 may also be involved in transcription regulation (By similarity).

Belongs to the NAC-alpha family.

22.072 kDa

MADPRVEELPEEEVKKTQVEDLDNSSDDESDIEAGDSSLPAGSQAVIHSRNEKKARKAIEKLHLQRVPGITRVTLRRPKNILFVINNPEVYKSPNSNTYIVFGEAKIEDLNASAQAAAAQQLASQSAEHDHAGHTHEHEEAGKAKEEEEEDEGEEVDAEGIEDKDIELVMTQANVSRKKAIKALKENDNDIVNSIMALSI