Function
Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience.
Sequence
MYRSTKGASKARRDQINAEIRNLKDLLPISDADKSRLSYLHIMSLACMYTRKSVFFSQDITTASSAEETTGFLSFYELNELIQGMPGFLLLLTGEGKLLYLSDSVSDHLGHSMVDLVAQGDSVYDIIDTADHFIMRSNLVPPTSPDTDRLFRCRFNTSKSVRRQSAGNKLVLIRARCLSQTPSESSPGSYWTSNPVWVCFCAPLEPHTSRGGTASDRESTSASALESSFFLPCFRSQHSRDMRLHEAQESVSVYLGLNVEILRSQSWYSFLHPQDLSHASAQHCSLLREGGEGRAEMVVRVETADHSWVWLYMVLQLETGETPIVSNNYIISETEAWSVRQQLSSEQTQLSLVLGSSTSQQESVSLQSPETLSSPDQVFTPGSSGLSGQSFDFSTAACSTGSTEEQGGSSSMEPAQVESGPRSSLSSMEEETFFQHEPSEPMASPSSASSPIPVTVATVSDLDFLTQNILLPPAFQIDPPLPVLPLPLPPVPTSQAQQTKEFVCTPPYTPQLGGSNFPFGEPHFSFDPTGATSPPPLGQTATVTTTTAPSLSPSAPSNPQSSPPPPTTTLSSLLPLTITSPTTEILFPVEPCSGSLYEKLPPTPDSPGDGDCTVMTLPEVRGPLYVDVPHGPLPYPPEGLLTPEASPGKQPSLPFFSSLRDREKERTEISLLAQHISTLAEGFYLDPLLAKLVPSTLSEHSQSPDSDGLDSIPLLGEFYPLKSWKGLDLPIFQDDESLFEESVLETLLQDLSSSPPLSPTPSSSSHSSPPSSPSTPECWCPSLHFDGVSAVSAGHFCSVQSAHCNNEAGRGAMMSPVNAGNMTDTKAAGEVPMETDVASSPLFTGIPTSPPLQLTASPASPILMPVSSPVSPPSPGLPCAQSLLEELAALEPMFGAGASIAPGLGQQPELYQLQSHVPQQCFRKDGSGSDPPF