Protein
Decarboxylase NovR
Organism
Streptomyces niveus
Function
May mediate the 2 consecutive oxidative decarboxylation steps in the biosynthesis of the prenylated hydroxybenzoic acid moiety of novobiocin, an aminocoumarin family antibiotic that targets bacterial DNA gyrases.
Similarity
Belongs to the aldolase class II family.
Sequence
MSEALANMPGDDYFRQPPVFDTYAEHRAYLKFRHAVALRHFARLGFDQDGLAGLITVADPEHADTYWANPLAHPFSTITPADLIRVDGDSAETVEGQRRVNIAAFNIHAEIHRARPDVQAVIHLHTVYGRAFSAFARKLPPLTQDACPFFEDHEVFDDFTGLVLAKDDGRRIAKQLRGHKAILLKNHGLVTVGETLDAAAWWFTLLDTCCHVQLLADAAGKPEEIPAEVARLTGRQLGSHLLGWNSYQPLHEAALARDPDLATMEPALPS