notum2

Gene

notum2

Protein

Carboxylesterase notum2

Organism

Danio rerio

Length

495 amino acids

Function

Carboxylesterase that mediates deacylation of target proteins (By similarity). Acts as a regulator of growth cone migration. Does not act as an inhibitor of Wnt signaling (PubMed:23365253).

Similarity

Belongs to the pectinacetylesterase family. Notum subfamily.

Mass

54.411 kDa

Sequence

MNIFCHALFLLLLGVVSCQNNNRNVKPGGKPAKKPNNPAIEATQHGPEADPNSGLAGAGDSSKETNPGGRGSSQQSASVNKPADDMKLHFLKNTAVTCNDGTAAGFYLKEFKGSKRWLIFLEGGWCCYSKETCDSRYKTIPRLMGSTDWPQTRRGSGLLSAQVDENPHWYNANIVFVPYCSSDVWSGNKAASKPKQGKETEYAFMGSQIIREVIKDLVPKGLKQAKVVMLAGTSAGGTGVLLNIDKVSSLLEQQGAEAQVRGLVDSGWFLESKQQKVPDCPDSASCTPADAIKKGLRLWNGVVPEKCKQQYKRGEDWHCFFGHKLYSYISAPLFVVQWLFDEEQLRVENIYMGSQSLSEQQWTYMQNLGKELKNSLKDVTAVFAPSCLSHTLITKSNWTDFQIKGTSLSRALQCWDRSFQEANKNSKTALKGCPFHLIDNCQWPQCNPTCPALIDQATQQEMTLLQVLASMGLDLQKLGLDVRGDISAGMVSNGG

Protein

Carboxylesterase notum2: notum2

Gene

notum2

Protein

Palmitoleoyl-protein carboxylesterase notum2

Organism

Xenopus laevis

Length

486 amino acids

Function

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleylation of WNT proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.

Similarity

Belongs to the pectinacetylesterase family. Notum subfamily.

Mass

55.452 kDa

Sequence

MRILEIFAILLILKEVRPQTKRSHKVNMKTPFQKRKNHHLNTDSRATLMSPADLHSVEHSIVQIRDPTLIPHYDQKSQEDMKLHFLKNTLVTCNDGTTAGYYLRETKGSKRWIIFLEGGWCCYSKETCGVRYDNVKRLMSSSNWPQTRKGTGILSPRQDENPYWWNVNAVFVPYCSSDVWSGNVSKTQDGYAFMGSVIIQEVIRDLVPRGMKQAKSVILAGSSAGGTGVLINIDRVAALVEETTSESVQVRGLVDSGWFLDSRHSKQSDCLDISKCALTEAIKKGLKLWNGILPENCKQQFKKGDEWRCFYGPRLFTSMKSPIFVVQWLYDQEQLRIENIQTEFQSMTENQWNSIQNIGREFKKSLREVPAVFAPACLSHTLITKSNWLEFQVKSVTLAKALHCWDRSLQENRAPKGVIRGCPFHLVDNCQWPHCNPTCPAIYDATSGQELSILQMFLKLRLESQRRGQEPKGDLGPLMSMLRNSG

Protein

Palmitoleoyl-protein carboxylesterase notum2: notum2