Protein
Serine/threonine-protein kinase Smg1
Organism
Drosophila melanogaster
Function
Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1.
Similarity
Belongs to the PI3/PI4-kinase family.
Sequence
MKNAIHPENCNGAGTEEEASSAFHAEIDRVLLNNNGNHGDSSNEGGGGNGSGRGGATGSGNIAGLGGSESMWSPGGGKSHDVAQAFANALLLRNMNHVVGKGQPVVQNHRKAYQCKGDTINPMANGEDLRLSKIIRRLINENNPTVSLELCSKLDQAVRTPINMGYMTCSFVWILDNMLTLYKQCPPPVLEECSKTLGLIGFINRKSYPIYEEFIVKNYKSSKRMQKYMIMALRATLSCDTKCELHMYADKIMLLLKDFLENAESADIFIVVSNTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQPTDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVGAFVGAFNTLLKCLARMQIFVGMPTCECIVKMAVDHLIKIMPTLHLNTEALVNINELICICLLNNFTGLDPILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIFQSNPYMTKVRLRSPGETSYKLLLRTCQETLLIRNVPLLQQAYKYLVDDIDACLEKLLITAPRSKARKASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELKFWSKYPAAQQAIFGLLVVHCQANHNFRTNSSLLRDQELSAENTSPTANSFASILRFLDSVLGQAHQLAPQNLRVLLQWIQMLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACIQTVLDYGLERLEKYPKLLILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQQRISQYSAVRDNVFRDFFDRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNLSQCTKRCQRLAIAWLQFEAARYCVDQRLRTTVGKPQETFLGFEAIIMRHARLLSGCAKEIERSALDDLSLEELLSMQSNLSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDLLCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQESADGGGAGGLGVGDLKYHKKDKNKGKPLDSDVKRQPFLSKLGMLQKYWSTNKTELMPQLEEMEQEVGNLQAAQAKQVVAEEELVKLNQRSALIAEIKSLGTAIESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQLYHLLDLQGQLVKLQMESNSENAREFSALTEALQLSGLDSMRSQLNELLGRMDMVAQKSSKHLQEYAGVMNFYPEQSHRQNLFVRFHDSFATYIQNGYTADSTTNTNSPSSSIICKADVVGVAEAMEYSWERLGCQLHEASKLYAANQAQALTLGAPTTALLSMIVQSGCSQLLLKASLVRTLDRAGGAFAAYEQVALASHDDGLLHHQLLFIHLVRTMLQGVLVMTKEEDQHLAQLESLLSALSHLKKMFEYDLPANLYRLLLLQPNLGKLSALCHLSASSLAQLFLEATMENGHKPPDQFPVERRFLLTLQPVYDQFLLASTSLDSLVSSMQSMLEDVHDVQTQQIMELGLMRSCHTELNDECFFGLVSEALESSRTCDVREMARPMLGFIHRLQVEKLAGLLPILTRNFYTAVGPQCLPTASCGDPAQADHLCESLFISLQSDGALLQQQAEIALLSQQVDLHTLAASAQYWAYSEALGSQLRCGPHIVSRPKLTAAIGECWLELDQKLTALQQLQAGLESQLSQLQTQRSNWNRNHIDNLLRMEQCNKQRTMSHVALLQKMTDGAGAVARLEQNAIVVGEEGQALVDHLEQWLAAHGQWQASSSRISAVEQSMVELLDPEGAIDHYWLENVQGLLEEQTCKVHREIAAIEGEQQSKHRFICTLLKETLRLLENMPRFHVQSLCSEAQAQGQGKMEYANVQLLSDHLREGQGLMQSLYMRLQELRKDICSDRRVLQPSMLQNWRHQLEMILTLAKQEVNEFFKGLEDFMQHAGETDSYEIFTHAKGSGNVHEQKRNAYGVSVWKKIRMKLEGRDPDSNQRSTVAEQVDYVIREACNPENLAVLYEGWTPWV