nodal3-b

Nodal homolog 3-B

401 amino acids

Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation. The unprocessed protein antagonizes bmp-signaling (By similarity).

Belongs to the TGF-beta family.

46.044 kDa

MALLNLFFCLVFSSPLMAMPPVLQGRKSMSPDSILKDTSTDDGARDFQGRKFPQFMMQLYQNIIRGRDKDLSNLEHPTLQESDTVQSFITKSYTTVGNHWTLFFDMSSISRSNELKLAELRFSLPSFRKSHSVTVDIYHTNDGKEKLFMGSFKTKPSAALDADCKVFNLTILLQNFLTRGKRLIKDEYIQAKGLHLKDLEKSATEKGTENVDTLKQDQYHVSDFAAERIMLVVFAKEQSHAKSDPPSLGKKLFPSKYGIDDNANKVNGFRRLRRNKKEKTQIHVSTGPPKPIEEIKPKCKKVDMFVDFQKIGWGSWIVYPKAYNAYRCESTCAVPLNETENATNHSYIKSLLPLSDMERKECPSCVPVKMMSMSMLYYENEDFILRHHEEMIVEECGFKDM

nodal3-B

Nodal homolog 3-B

401 amino acids

Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation (By similarity). The unprocessed protein antagonizes bmp-signaling.

Belongs to the TGF-beta family.

45.849 kDa

MAFLSLFLCLVFSSPLMAMPPALQGRKAISPASILKGPSTDNGARDFHGRKFPHFMMQLYQNIISRRDKDLSNLEHPTLQESDTVQSFIAKSYTTVGNHWTLFFDMSSISTNNELKLAELRICLPSFGKSHSVTVEIYHTKDTKEKLFMGSFKTKISSALDADCKVFNLTMVLHNYLIRGKRLIKDEYIQAKGLLLRDLEKSAAEKGAENVDTLKQDKHHVSDFAAERIILVVFAKERSQAKPDPPSLGKQLFPLKYGMADNANKVNGFRRLRRNKKEKTRMDVGTTPPKPVEEIKPKCRKVDMFVDFQKIGWGSWIVYPKAYNAYRCESACAVPLNETDDATNYSYIKSLLPLSDTERRECPSCVPVKMRSMSMLYYENEEFILRHHEEMIVEECGFKDI