Protein
Protein N-terminal and lysine N-methyltransferase EFM7
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Function
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha (TEF1 and TEF2), before also catalyzing the mono- and dimethylation of 'Lys-3' (PubMed:21858014, PubMed:26545399). May be involved in rDNA silencing and in lifespan determination (PubMed:12736687).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
Sequence
MSDIESLGEAAGLFEEPEDFLPPPPKPHFAEYQRSHITKESKSDVKDIKLRLVGTSPLWGHLLWNAGIYTANHLDSHPELIKGKTVLELGAAAALPSVICALNGAQMVVSTDYPDPDLMQNIDYNIKSNVPEDFNNVSTEGYIWGNDYSPLLAHIEKIGNNNGKFDLIILSDLVFNHTEHHKLLQTTKDLLAEKGQALVVFSPHRPKLLEKDLEFFELAKNEFHLVPQLIEMVNWKPMFDEDEETIEVRSRVYAYYLTHEK