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nnt1

Gene
NNT1
Protein
Protein N-terminal and lysine N-methyltransferase EFM7
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
261 amino acids
Function
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha (TEF1 and TEF2), before also catalyzing the mono- and dimethylation of 'Lys-3' (PubMed:21858014, PubMed:26545399). May be involved in rDNA silencing and in lifespan determination (PubMed:12736687).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
Mass
29.633 kDa
Sequence
MSDIESLGEAAGLFEEPEDFLPPPPKPHFAEYQRSHITKESKSDVKDIKLRLVGTSPLWGHLLWNAGIYTANHLDSHPELIKGKTVLELGAAAALPSVICALNGAQMVVSTDYPDPDLMQNIDYNIKSNVPEDFNNVSTEGYIWGNDYSPLLAHIEKIGNNNGKFDLIILSDLVFNHTEHHKLLQTTKDLLAEKGQALVVFSPHRPKLLEKDLEFFELAKNEFHLVPQLIEMVNWKPMFDEDEETIEVRSRVYAYYLTHEK

Gene
NNT1
Protein
Protein N-terminal and lysine N-methyltransferase EFM7
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
261 amino acids
Function
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha (TEF1 and TEF2), before also catalyzing the mono- and dimethylation of 'Lys-3' (PubMed:21858014, PubMed:26545399). May be involved in rDNA silencing and in lifespan determination (PubMed:12736687).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
Mass
29.633 kDa
Sequence
MSDIESLGEAAGLFEEPEDFLPPPPKPHFAEYQRSHITKESKSDVKDIKLRLVGTSPLWGHLLWNAGIYTANHLDSHPELIKGKTVLELGAAAALPSVICALNGAQMVVSTDYPDPDLMQNIDYNIKSNVPEDFNNVSTEGYIWGNDYSPLLAHIEKIGNNNGKFDLIILSDLVFNHTEHHKLLQTTKDLLAEKGQALVVFSPHRPKLLEKDLEFFELAKNEFHLVPQLIEMVNWKPMFDEDEETIEVRSRVYAYYLTHEK

Gene
nnt1
Protein
Protein N-terminal and lysine N-methyltransferase efm7
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
255 amino acids
Function
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
Mass
28.49 kDa
Sequence
MADNDFEGFGIFEEPEGFRPSTPPPKEVLHTRVIVPNGPEEIKLRLVGSHSLWAHYLWNSGIELANYIDKNPDTVRAKKVLELGAGAGLPSIVSAFDGAKFVVSTDYPDPALIDNLEHNVKQYAEIASKISAVGYLWGSNIKEVMSNAGFKDNEVFDILLLSDLVFNHTEHSKLIKSCKMAIEGNPNAVVYVFFTHHRPHLAKKDMIFFDIAQSEGFQIEKILEEKRTPMFEEDPGAPEIRATVHGYKMTIPIPV

Gene
nnt1
Protein
Protein N-terminal and lysine N-methyltransferase efm7
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
255 amino acids
Function
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
Mass
28.49 kDa
Sequence
MADNDFEGFGIFEEPEGFRPSTPPPKEVLHTRVIVPNGPEEIKLRLVGSHSLWAHYLWNSGIELANYIDKNPDTVRAKKVLELGAGAGLPSIVSAFDGAKFVVSTDYPDPALIDNLEHNVKQYAEIASKISAVGYLWGSNIKEVMSNAGFKDNEVFDILLLSDLVFNHTEHSKLIKSCKMAIEGNPNAVVYVFFTHHRPHLAKKDMIFFDIAQSEGFQIEKILEEKRTPMFEEDPGAPEIRATVHGYKMTIPIPV