Protein
2-nitroimidazole nitrohydrolase
Organism
Mycobacterium sp. (strain JS330)
Function
Involved in the biodegradation of 2-Nitroimidazole (2NI) which is a natural antibiotic and an analog of the synthetic nitroimidazoles used for treatment of tuberculosis, Chagas disease and cancer. Catalyzes the hydrolytic denitration of 2NI to produce imidazol-2-one and nitrite. It is also active against the 2NI synthetic derivative benznidazole. NnhA confers drug resistance to 2NI.
Similarity
Belongs to the arginine deiminase family.
Sequence
MTTVDKRPSSRGYGDWRLSDIPQYKDGISTYEFVRATHEADYRTHQAEPVAGRTFGFNGIGRLTEVALHMPTKYTLHDQSSQYKESPSFFQGLMGVPDRGPVDLAAFQRETEELATAFENNGIKVHWVDYPEEPANPYGPLMGHVFLSWGSIWRGGSVISRFGFLPGMVGVSEYLAKWAWNTLNIPPLVAITEGAMEPGACNMIADEVLVTCLSASYDQRGTDQLVAAISKTSGTEEFHNLQLRPAVEGFFNKATGACAHPDININAIDVGKLVVSPAALDWDARTWLYDNNFELIEADPDEQREFLAPCNVLLLEPGKVIAHADCHKTNQKIRDAGVEVIEVTGTEIRKACGGIKCRVMQINREPGPTLADVRNRVWR