Protein
Nuclear distribution protein nudF-2
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Similarity
Belongs to the WD repeat LIS1/nudF family.
Sequence
MSQILTSRQADELHRALIAYLTAANLPNTAAALREELNLSEEVFDPATAKKYEGLLEKKWTSVVRLQKKIMDLESRNHILQSELDNATPTSRQNKDPVAWLPRAPPRHTLQSHRDPITCVAFHPVFSSLASGSEDQTIKIWDWELGELERTIKGHTKAVLDVDYGGPRGNTLLASCSSDLTIKLWDPLDSYKNIRTLPGHDHSVSAVRFIPGSGNLLVSASRDKTLRIWDVSTGYCVKTLRGHAEWVRDVCPSLDGKYILSTSDDYTSRLWDVTITNPEPKVTLIGHEHVVLCCAIAPPAAYQNLAAMAGIKKPPATSSAEFMATGSRDKSIRLWDARGTCIKTLVGHDNWVRGLVFHPGGKYLLSVSDDKTLRCWDLTQEGKCVKTIGDAHGHFVQCIKWAPSVIKDASVNGDNGEPNGTPKKGGAAATPEAQIRCVIATGSVDLNVRIFAN