Protein
DNA N6-methyl adenine demethylase
Organism
Caenorhabditis elegans
Function
Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance.
Similarity
Belongs to the alkB family.
Sequence
MGSAEQACGCKGARFCALCETTERVKKLRVVEDKHVNYKVFIYDHIRQIAIPTTNLNSQSSLEDIIDESTSCQSVSTDGSIEIDGLTLIHNFLSESEESKILNMIDTVEWAQSQSGRRKQDYGPKVNFKHKKVKTDTFVGMPEYADMLLNKMSEYDVKKLGNYQPFEMCNLEYEEVKKSAIEMHQDDMWIWGNRLISINLINGSVMTLSNDNKSFLCYVHMPHRSLLCMADECRYDWKHGVLAHHIRGRRIALTMREAAKDFAEGGELYEKYGAELIRLGNIRVPLSKTSV