Protein
Molybdenum cofactor sulfurase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Similarity
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
Sequence
MGSLNIQHNGYDADVEKIREEEYPMLKDSIYLDHAGTTPYPKSLMDRFAQEMTTNLFGNPHSASASSQLSTQRIQDIRLRALQFFNADPADFDLVFVANATAGIKLVVEAMRCLPTGFDYVYHQSSHTSLVGVREEARSSVCLDTRQVEDWLSGSCPFDDNEDEERPILFAYPAQSNMDGRRFPLSWSSQICRQSLSPTNKRKTYTLLDAAALVSSSPLDLSNAETAPDFVVLSFYKIFGFPDLGALIVRKEVQDVFLSRRYFGGGTVDMVVCLKEQWHAPKDGFLHERLEDGTLPIHSIIALDVAMDVHAKLFGSMERVAGHTGFLARRLYQGLKGLRHANDELVCAIYSPDPETEESGPLVAFNIRNAQGIWISLAEVEKLATLKGIHIRTGGVCNPGGIASALGLEPWEMKQNFSSGFRCGTDNDTMGGKPTGIIRVSLGAMSTIADVDRFVQFVKEFYCEDTPPILPPPETKLDPSLRNTPELFIKSIVVYPIKSCAGFHVPPGIDWEVRPEGLVWDREWCLVHRGSGQALSQKRYPRMALLRPNLDFTKGELQVTFAGDISSSPGLPSSISVPLSKNPKMYAPKKSGMSSRVCGEEITPQTYASAQINDFFSTVLGVPCVLARFPPGGQGKGMTRHAKAHLQRHQHQQPHPAVSVSTRLTKPAMMPGAFPSPKAVETPPSPPDSDTERSATPTQEAQGPKPRRILLSNESPILAITSTSVDALNQSIALLNPSVSQPISEAVFRANLVLSPSPSTPSASPSNPLTPSPSPSTTSKPTPKPKQKPKQKLNPYEEDTWSSLTIFNSSSFSSSSSSCSTPSSSGFQTTTKFQMLGSCRRCHMVCIDQTTGSKTAGGEPFVTLSKTRRFEGKVFFGVHMGLQAEDEEDGHAEDIEKEGTGMGMGTGTGTGTGTRSMGGNGSVVKVRVGDVVRPSYL