Protein
Uroporphyrinogen-III C-methyltransferase
Organism
Paracoccus denitrificans (strain Pd 1222)
Function
Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin (By similarity). Inactivation of uroporphyrinogen-III methyltransferase results in the loss of nitrite and nitric oxide reductase activities, but not of nitrous oxide reductase activity. Likely involved in heme D1 biosynthesis.
Similarity
Belongs to the precorrin methyltransferase family.
Sequence
MAGKTVTNGAAQGKAARSGADGAVRGKAGMGRVDLIGAGPGDPELLTLRALRLLQQADVVVHDRLVSDEVMACIPAHVRRIPVGKAAGFHPVPQEQINALLVELGLSGLTVARLKGGDPTIFGRGGEEFEAVTRAGIPCDYVPGITAAQGAAVSARFPLTHRGLATGLRHVTGHRARDAALDLDWASLADPQTTLAIYMGAANMAEIARELIRHGMPADLPVLAVSQASTPQEQRLHATLQDIAAALARKPLPAPVLFIVGHVAAMAEDCALPQELYRPEWRLVAHG