Protein
Na(+)/H(+) antiporter NhaC
Organism
Bacillus subtilis (strain 168)
Function
Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on growth and on alkaline phosphatases production in the presence of sodium, by affecting the transcription of the phoP/phoR two-component regulatory system.
Similarity
Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter family.
Sequence
MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVMLSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALSFIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGACFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAASTDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFVPYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIGLISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQRKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGFVKK