Nes

Nestin

1893 amino acids

Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

Belongs to the intermediate filament family.

208.797 kDa

MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDTSWRARADDELASLRILVDQRWREKLEAEVQRDNLAEELESVAGRCQQVRLARERTVQEAACSRRALEAEKNARGWLSTQAAELERELEALRAAHEEERAHLNAQAACAPRRPPAPPHGSPVRAPEVEDLARRLGEVWRGAVRDYQERVAHMESSLGQARERLSQAVRGARECRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATDKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRGSQASLGFLDPKLKPNFLGIPEDQYLGSVLPALSPTSFPSPLPNTLETPVTAFLKTQEFLQARTPTLASTPIPPISEAPCPPNAEVRAQEVPLSLLQTQAPEPLWAEATVPSSSAILPELEEPGGKQQGHFPDDLTSLATTLNPHHPTLEAKDGESSGSRVSSIFQEDEGQIWELVEKEADIEVKVENSSAQKTQESGLDTEETQDSQGPLQKETLKALGEEPLMSLKIQNYETAGKENCNSSTEGHLGTLEGPEKEKQIPLKSLEEKNVESEKTLENGVPVLSELLGKEDTRTEDQELMSPKGTLKRFSSLGKESQEVVRPSKEGNLESWTAFKEESQHPLGFPGAEDQMLERLVEKEDQSFPRSPEEEDQEACRPLQKENQEPLGYEEAEGQILERLIEKESQESLRSPEEEDQEAGRSLQKGNQEPLGYEEAEGQILERLIEKESQESLRSAEEEDQEACRSLQKENQEPLGYEEAEDQILERLIEKESQESLRSPEEEDQEAGRSLQKENQEPLGYEEAEDQMLERLIEKESQESLKSPEENQRIGKPLERENQKSLRYLEENQETFVPLESRNQRPLRSLEVEEEEQRIVKPLEKVSQDSLGSLAEENVQPLRYLEEDNCINKSLLEDKTHKSLGSLEDRNGDSIIIPQESETQVSLRPPEEEDQRIVNHLEKESQEFSRSSEEEERVMERSLEGENHESLSSVEKEDQMVESQLEKESQDSGKSLEDESQETFGPLEKENAESLRSLAGQDQEEQKLEQETQQTLRAVGNEQMAVSPPEKVDPELPKPLGNDQEIARSLGKENQESLVSLKEKGIETVKSLETEIIEPLETAEEDLERRKSIDTQEPLWSTEVARETVEPPEDEPPGSLGSVDENRETLTSLEKESQELSSLGKWNVETRVEDSQQCLQVEEGLQEEQHQESLREVKQELPSSGNQQRWEDVVEGKAVGQEAPLATTGVGTEDKAELHLRGQGGEEEAAAEGELLQDIVGEAWSLGSSEPKEQRVPAEALDNLEGGALEVPVAQSMPEVTERDEDRAQAGEQDSIEVTLGLEAARTGLELEQEVVGLEDPRHFAREEAIPPSLGEESVKAKIAQGLEGPGKEPKEAGALDSGILELPKTSSEALECQGHEESESMEGWEEEEASLETSDHEGSDAPQPRPPETEEDEGAQAALTAPGPKLLEPCSPIPILTDAHELQPQAEGIQEAGWQPEAGSEALERVENEPEFGLGEIPEGLQDWEEGREESEADDLGETLPDSTPLGLYLRSPASPKWDLAGEQRLSPQGDAGKEDWGPAVPAAQGLSGPPEEEEEQGHGSDLSSEEFEDLGTEASLLPGVPKEVADHVGQVPPVLQPACWDQGGESDGFADEEESGEEGEEEDADEEGAESGAQWWGSGASGGGCKVQDIAQRGDPVQESVGVSGLWDDGLRGAAANVPALEMVSQDSAEPSGSEESESASLEGEEGQVTDHLDAPQEVTSMVPGVGDAFDIGGQSPNLDSEQVNGKMENGLEQAEGQVVLDGDEDQELLLQGQEVGALKVPLVASPVHLGPSQPLKFTLSGVDGDSWSSGED

Nes

Nestin

1864 amino acids

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity). Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

Belongs to the intermediate filament family.

207.124 kDa

MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDASWRARADDELAALRVLVDQRWREKHEAEVQRDNLAEELESVAGRCQQVRLARERTIEEAACSRRALEAEKNARGWLSTQAAELERELEALRASHEEERAHLNAQAACTPRRPPAPAHASPIRAPEVEELARRLGEVWRGAVRDYQERVAHMESSLGQARERLGQAVRGARESRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATEKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRSSQASLGFPDPKLKLHFLGIPEDQHLGSVLPVLSPTSFSSPLPNTLETPVTAFLKTQEFLKARTPTLASTPIPPMSEAPYPKNAEVRAQDVPHSLLQGGRQQAPEPLWAEATVPSSTGVLPELEEPGGEQPDHFPDDPTSLAPPLNPHHSILEAKDRESSESRVSSIFQEEEGQIWELVKKEAATEVKVENSLAQEIQESGLDTEEIQDSQGPLQMETLEALGDEPLMSLKTQNHETPGKENCNSSIEENSGTVKSPEKEKQTPLKSLEEKNVEAEKTLENGVLELSKPLGEEEPRMEDQELMSPEHTLETVSFLGKENQEVVRSSEEQNLESLITFKEESQYPLGGPEAEDQMLERLVEKEDQRFPRSPEEDQQAFRPLEKENQEPLRFEEAEDQVLERLIEKERQESLKSPEEEDQQAFRLLEKENQEPLRFEDAEDQVLERLIEKERQESLKSPEEEDQQAFRLLEKENQEPLRFEEAEDQVLERLVEKESQESLKSPEEEDQRTGKPLEKENQESLRSLDENQETIVLLESKNQRPLRSLEVEEEEQRIVKPLEKVSQVSLESLEKENVQSPRYLEEDDHMIKSLLEDKTHEILGSLEDRNGENFIPPENETQGSLRPPEEEDQRIVNHLEKESQEFLRSPEAEEEEEQVMVRSLEGENHDPLSSVVKEEQMAESKLENESQDSRKSLEDESQETFGSLEKENLESLRSLAGQDQEEQKLEQETQQPLRAVEDEQMTVNPPEKVDPELPKPLRNDQEVVRSLDKENQESLVSLNEGGMETVKSSETENIESLETVGECLGRRKSVDTQEPLWSTEVTSETIEPLEDETQEPLGCVDENQEVLTPLERESQELRSLGKWNPETVESPGGVEDSQQCLEVEEGPEREQHQESLRSLGEVEWELPGSGSQQRWEDVVEDGEGQEASLGATGVETEDKAELHLRGQGGEEKAVEEGELLQDAVGEAWSLGSSEPKEQRVPAEPLDDLEGQPEQTGTLEVPVAQGMPEATEQDEDRAQAGEQDSVEVTLGLEAARAGLELEQEVVGLEDPRHFAREEAIHPSLGEESVKAKIDQGLEEPGKEPKEAGALDSGIPELPKTSSETLECKGWEESGEGWGEEEASLETSDHEGSHAPQPRPPKTEEDEGLQAALTVPGPKLLEPCSPIPILTDAHELQPQAEGIQEAGWQPEAGTEALGRVEDEPEFGRGEIPEGLQDWEEGREDSEADELGETLPDSTPLGLYLKSPASPKWEQAGEQRLFPQGEARKEGWSPAALAAQGLSDPPEEEQQGHDSDLSSEEFEDLGTEASLLPGVPKEVSDHLGQEPPVLQPACWDQGGESDGFADEEESGEEGEEEDADEEEGAESGTQWWGPGPSGGGVKVQDVTQRGDLEHESVGDSGLWDDGLSGAAANVLVTALETVSQDSAEPSGSEGSESASLEGEEGQAIDHLDAPQEVTSVVPGAGDTFDISGQGPNLESEQVNGRMENGLEQAEGQVVLHGDEDQGIPLQEQGTLKAPLVGSPVHLGPSQPLKFTLSGVDGDSWSSGED

NES

Nestin

1818 amino acids

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Belongs to the intermediate filament family.

200.577 kDa

multiple

WREKLEAEVQRQNLYQERVAHMESSLGQARERLGRAVRGAREGRLELQQLQAERDGLQERREALEQRLEGRWQDRLQATEKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRSSQASLGFQDPKLKLRFLGTPENQHLGSVLPVLSPTPLPSPLPDTLETPVTAFLKTQEFLQARIPTLASTPIPPMTEAPCLAKAEVRAQDAPLSLLQTQGERQQAPEPLWAKATASVSTGVLTELEEAGGQQPGHFPEDATASAPSLSPHHPVLEAKDGDSTESRGSSIFQEDEGQIWELVEKEAAIELKVESSLAQETQEDGLHTEEIQDSQGPLQKETLEALGEEPLMSLKIQNHETPGKENCNSLRSVDENQGTLKSPEEEKQTLLKSLEEKDVEVEKTLEKGVPELSKPLGKEDPRIEDQELMSPEGTLETLSFIGKRNEEVVRSSEEENIESLAAFKKESQHPLGCPEEEIQRVERLIEKEGQESLSSPEEEDQETDRPLEKENGEPLKPVEEEDQLFETLIEKEGQESLSSPEEEDQETDRPLEKEEDQLVERLVEKEGQESLSSPEEEDQETDRPLEKENGEPLKPVEEEDQLFETLIEKEGQESLSSPEEEDQETDRPLEKEEDQLVERLVEKEGQESLSSPEEEDQETDRPLEKEEDQLVETLIEKQGQECLSSPEEEDQETDRPLEKEEDQRVERLIEKEGQESLSSPEEEDQETYRLLEKENGEPLKPVEEEDQRVERLIEKEDQESLSSLKEEDQRIVKTLERENWESLRSLDENLDTVMPLESKNQKPLKSLEAEEEQRIVKPLEKVSQDSIGSLEKENVELLRSLEDDQITESLLKKGTQESLESHEDRNQETQDPQRFLEEEGQGIVKQLEKENQGFLGSLEEEKVVKRSLERENHEPLSSVEKDWVTESLLERESQDSGKSLEGQEAFRCLGKEDPESLQFPEVQDQEIQRSLQQETQQTLGALGDEQMASEPPEKVGPELLKFLGNGQEIVRSLEEQNQESLVSVKETSVETAKSSDMEDIEPLKSADEDLEIINSAGAQESLWSMEVTRETTRPLEKEVQESLGFVGGNQEILRPLERGNEELGSLGKWNLEAVDSPEAVEEGRQPLGEEACLEMGEHQEPPRSLGEVEQGLPGSGNQQKWEDRAVENAAADQGPTLGRTGIESEDEAELPLSGQGEKEEDAEERELQLDAMGEAWSLASSEPQEPRVPSEGGSAGAPQGLEGQSEQVGVLGVPVGQGMPEVTEPLLQEDVAQAGKRDPIELTLGSDAATRAGLGLEQEVAGSGGSRHLAREEAIHPSLGEESVEAKIAHDLEGPGKEPKEAGALESEISELPRTSSDVLESKGCKQSEPVLGWAVEEASVEASDHEGSDAPEPRPSETEGDEGAQAALAPPGPKLMEPCSPTPILKDAYEWQPQAEGTRETGRQLEGGSASLERVEDEQEFGLGGIPEGLQDWEESREESEADELGETLPDSTPLGLYLRSPTSPKWDQAGEQRLSPQGEARKEGWGPAVPAAQGLSNPPGEEERGHDSDLSSEEFEDLGTEASLLPGLPKEVADHLGQVPPGPEPECWDQGGESDGFADEEESGEEGEEEEHEDGTESGAQWWGSGPSKVQHVTQRGDLQEHESVGISGPWDDGWRGAAAGISVTGLETESQDSAEPSGSEVSESVSSEGEDQAPDHLDTPQGVTNVVPGAGDTFGISGQAPNLESEHMNGRLENGLEQSEGQGVLDRHQDQGHPSQQQEVGALKAPLLGSPVHRGPSQSLEFPLSGADRDSWSSGED

NES

Nestin

1621 amino acids

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Belongs to the intermediate filament family.

177.439 kDa

MEGCMGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVGQGMPLVSEGDRGSPFQEEEGSALKTSWAGAPVHLGQGQFLKFTQREGDRESWSSGED

nes

Nestin

1265 amino acids

Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Required for brain and eye development.

Belongs to the intermediate filament family.

143.4 kDa

MELLGVRQPFGPQFQEEKYQMLELNHRLESYLGRVKLLEEENKLLREEIHTLKSSRDPAGQRKAQEEALSQARRMMEEAWRKKDCVELEVENLMEDMEKVSFQRKKVKTAQAEAQRKLTESRKELEEERRAQIWLREKVGQLEKDLMLQMQVHQENMETMQASLKQTKQVLMAPQRVQATSIPDLGQEYGYKAAQAWQEAANNYQKQVGRLEESLNQTKANMTKIYQEKRESQRQVQHLAKELESTRIKRQMLEKHAMQQREEQKEELQHLQAQVNTLELEKDCLGQQIDSLMLDRQHLLQVKMSLGLEVATYRALLDSEGLRIDRPTPNKTSSTVFLDALSKPTGIQSTSQTTAASCLLSSSVSTSHRSIASSRSLLTSAAPSWTLTRGTPQRPPSSTSMTEKTEDHISEETKRSAEESVDQLQQEKVQQDWTLESTLPKTSAEPKPELQPEEIKVEDEANEPQQAHMVESKTDESELTSVPAEQQGSMSQTPETKSWAGHFNDPAEVSEDGKDEDTEVSVEMARISHAPKVAWEEIKSAVEDEKDDASEMDVRSEIISESHTFAYGDAENDSNTLTSSHISQNTNALASSFLEQGTLDSASYFGYEATNENLMKEEELDNVSNISEEVTEQLNSETEAAIDSINEWDRQEESEPENETKVMTSYFEVEEGEMSINTDTKDKTEDDIEREELEVTEREILVQSAGGMLGVDLPNDTDHQDEHNLPQIELNEDQSEAEEENQKEKQCDEDDSPNISASLKTDPGEGDSYSQEHTLADTRPLIRYKSDEETSHHIGETSDSEDEKERIDQGHLNEKRFNTMEDLTEEPDMEVTGKMRLEDLVSNEEAAADDVASVMFQKVSGDHESLDVVVQESERKGNLEKEDSGDADNMRDNKEEDVSVFEQNENQQLTEHQHVHTEQVEDKPVHSHETQEHVNTEFSSTFSERSQQEQLEESSLTMFEDEAATKEAEDSDVSMHTNIDLIDSRSLESEINGQPDIMTSDMANSECNSSEDESPNASQCFQNTSLLAAATPNEQPLTFTNEVSKADYVSDNNDVPEEVLSEEKSTDEPKASQIDDLENFNIWGESTSISDAAQTTHASMDEHSSISPVNENLESSNKIPSVAENIFGHFEEHLERSVESFPEKEVTVMDFENNDLGEEFQSKQMKSEIHSFFSTSLKQDFWSEGKMEMAATYDPAKTEDLNQAMVFGEEWREIGVQSANGDTKEEMEILKIRDDKQKDGQPAQSKIVQSDDSADEGDSWSSGDE

nes

Lysophospholipid acyltransferase 5

497 amino acids

Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). May also catalyze the conversion of lysophosphatidylethanolamine (1-acyl-2-hydroxy-sn-glycero-3-phosphoethanolamine or LPE) to phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity), as well as the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has a preference for unsaturated fatty acids such as arachidonic acid.

Belongs to the membrane-bound acyltransferase family.

57.394 kDa

MAEFEEDLPHNGLMDGIASGVGVPVEALRLLLTILAGYPVAALYQKFISVIADKTVHHMFFAGCGAGLCYFNYGLDTYHSLIAILTTYFLVLLLRKKTQIFLAINFVFHMSYLLLGYFYTSSNDYDILWTMPHCILVLRMIGYGFDITDGLKEESELSKDQKETALKKPPSLLELLAFSYFPSGFLVGPQFPFRRYKAFVDGEFRQHEGNVEAGVRRFGAGAFYLIVCQVGLRYLPDSYFLTPEFAQVSFVKRIYLLGFWAKFSLYKYISCWLLTEGALICIGLTYKGEDKNGQPDWSGCSNVKLKLLETGNTMEHYVQSFNVNTNQWVGQYIYKRLKFLNNRTISYGAALGFLAVWHGYHSGYYMTFLMEYMVVSTEKQITRFYTKVVLPQWGHILNNSDIYKLLYFITLKSYNVVYMGWCLTAFVFLKYERWIVVYGAVSYYGFTFLVLWAAFYHTFNHFFRSSSRKLAGEDQKLQDSNTDKLVEEKKPEDKKSE