Protein
Nicotine metabolites export pump subunit NepB
Organism
Paenarthrobacter nicotinovorans
Function
Component of an efflux pump responsible for the transport of nicotine breakdown products, in particular methylamine, out of the cell. This pump apparently serves as a metabolic valve for nicotine catabolites and may protect the bacteria from the potentially toxic side effects of these compounds.
Similarity
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. NepA/NepB subfamily.
Sequence
MSSYARRTPVRTVLNFCTAIRQIITGEAGSVAADKGNRGQKRAPLLHRHRLHAWLYLGSAITTEVTGTVILDFSEGFQLPAQTTAAMALYAFSFFLLTRALRAVPLSVAYATWSGLGTVAVAFAGAIIHGEAVTLGRITAITAVIGGIVILNLATTRQHSARRKDV