Protein
UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase
Organism
Streptomyces fradiae
Function
Glycosyltransferase involved in the biosynthesis of neomycin by mediating glycosylation of ribostamycin with UDP-GlcNAc as a sugar donor to generate 2'''-acetyl-6'''-hydroxyneomycin C.
Similarity
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Sequence
MAEAPAGRALFEIYDEGFDSPSWGGVETALWHLSRSLREAGTEAEFYRSSEGADLDALAARVERDRVDAVFPLVESDLFEGAAWRRLPALHARTVRVWHDVSRLSADLSAPPPCPVHARVPALPGAPVAEGCPARGAHPEGPMREVFLGEWPWTRCFPRRSVIPWAADHVPAKDLCDPSGPVVLQLGKIDTVDAERCLRRLTGAGVALRVVFATWSRRGREARELVRAHQGAGRRVEVLDAYDIRTDWERVFGGASLFLLPSVFHETYNFAAAEAVQLGVPVAALGEGGNLPRFASLTAPTPDALVDRLLAGGGAVAPRPRPAAGWRDVAARYAEVIREHPAAGAGPAVPAGAGEGRGGREEEHGG