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nemR

Gene
nemR
Protein
HTH-type transcriptional repressor NemR
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
199 amino acids
Function
Involved in response to both electrophiles and reactive chlorine species (RCS). Represses the transcription of the nemRA-gloA operon by binding to the NemR box.
Mass
22.275 kDa
Sequence
MNKHTEHDTREHLLATGEQLCLQRGFTGMGLSELLKTAEVPKGSFYHYFRSKEAFGVAMLERHYAAYHQRLTELLQSGEGNYRDRILAYYQQTLNQFCQHGTISGCLTVKLSAEVCDLSEDMRSAMDKGARGVIALLSQALENGRENHCLTFCGEPLQQAQVLYALWLGANLQAKISRSFEPLENALAHVKNIIATPAV

Gene
nemR
Protein
HTH-type transcriptional repressor NemR
Organism
Escherichia coli (strain K12)
Length
199 amino acids
Function
Involved in response to both electrophiles and reactive chlorine species (RCS) (PubMed:23506073, PubMed:23536188). Represses the transcription of the nemRA-gloA operon by binding to the NemR box (PubMed:18567656, PubMed:23506073, PubMed:23536188). May sense electrophiles, primarily quinones and glyoxals, as redox signals and regulate the redox state by modulating the expression of nemA and gloA (PubMed:23506073). Also uses the oxidation status of HOCl-sensitive cysteine residues to respond to bleach and related RCS (PubMed:23536188). Involved in response to methylglyoxal (PubMed:23646895).
Mass
22.275 kDa
Sequence
MNKHTEHDTREHLLATGEQLCLQRGFTGMGLSELLKTAEVPKGSFYHYFRSKEAFGVAMLERHYAAYHQRLTELLQSGEGNYRDRILAYYQQTLNQFCQHGTISGCLTVKLSAEVCDLSEDMRSAMDKGARGVIALLSQALENGRENHCLTFCGEPLQQAQVLYALWLGANLQAKISRSFEPLENALAHVKNIIATPAV