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ndel1-a

Gene
ndel1-a
Protein
Nuclear distribution protein nudE-like 1-A
Organism
Xenopus laevis
Length
345 amino acids
Function
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts.
Similarity
Belongs to the nudE family.
Mass
38.622 kDa
Sequence
MENEEIPEFLSPKEEIVYWRELSKRLKQSYQEARDELIEFQEGSRELEAELETQLVQAEQRNRDLLSDNQRLKCEVESLKEKLEHQYAQSYKQVSLLEDELARARSIKDQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQTDGTRKSAPSSPTLDCDKTDSAVQASLSLPATPVGKICDNSFTSPKGIPNGFGTTPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYTPVNLNSNSSSSVLNSSGVKYSHAGHTSFFDKGAVNGYEPPGVLGSRPPSPPGMLPLSV