ncoa2

Nuclear receptor coactivator 2

1516 amino acids

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (By similarity). Required in a nuclear receptor pathway to suppress expression of dorsal mesoderm genes. May play a role in the positive regulation of the circadian clock (By similarity).

Belongs to the SRC/p160 nuclear receptor coactivator family.

166.156 kDa

MGENLSDPSRAEPRKRKESLDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNLNFKPDKCAILKETVKQIRQIKEHEKTAAANEDEVQKADVSSTGQSVIDKDALGPMMLEALDGFFFVVNREGNVVFVSENVTQYLRYNQEELMNTSVYSILHVGDHSEFIKNLLPKSLVNGVPRRNSHTFNCRMLVKPMMECEEERHDGQETHQKYESMQCFAVSQPKSIKEEGEDFQSCLICVARRVPVKERPVPPPSESFTTRQDFQGKITSLDTTSMRALMRPGWEDMVRRCIQRFHSQHDGEISYSRRHHQEVLRQGHATSPFYRFSLSDGTTVVAQTKSRLMRSQTNNEPPLVLSLHVLQREQNVCGLNQDLAGQAMGKTLNPVQSSSPAHQAMYGGNPGQDTTISSNMNYAISGPKEQMGLATGRFVGSGGMNHISSLQATTPQGNNYALKMNSPSHGSPGMGQGQPNSMLSPRHRVSPGVAGSPRIAPSPFSPAGSLHSPVSVCSSTGNSHSYTNSSLNALQALSEGQGPLAPPLSSPDLKGGNLQHSPGNMNPPQLRKMGSIDSKESFGLYEEQPESATGQGESGCHSNEQKDCGENLSSVVDKTEGQSRLLDGKGQQKLLKLLTTKSDQMEPSTLPSNTLGDMNKDSLSNFASNSMSASAHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESNSTGPGSEVTIKQEPVSPKKKEHALLRYLLDKDDTTDNVADITPKLERADNKVDPSSCPKLSAVKAEKEEPNFGHTDQPGSDFDNLDEILDDLQNSQLSQLFSDTRHDGNSADKQAIMNDLMQLAGENSTGLPAWAQKQRMLRMQQNNGFNSQLAAQLGRLPNQNLPLDIHFQSQASAGSFAQMRSSGPYTTVPQSGVINNQAMMGSQGNVRNSSPGIVGVNGPRPPLKPGDWGSQASAVRPACPTTSTAMNRHDMSRSPTASIPMRPGSQVCPRQVLQSAVMNMGSSELDMNISGPQYTQQQAPPNQTAPWPNRILTIEQPSFNNQNRQPFGSPADDLICQPIVSESPADDGNLLDQLYMALRNFDGLEEIDRALGIPEMVSQGQAVEQESFGSPESNLMMEQKPPVYNHAYANQGQMAQNSYQPMQDPGFNPMGQRPSYGILRMQNRPGLRPTGMVQNQPNQLRLQLQHRLQAQNRQQLMNPINNVSNMNLAMRPGVPGQLREQGPINAQMLAQRQREILSQHLRQKQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHRAMMMRSQGLAMPPNMVGSGGIPASINSPRIPQGSTQQFPFPPNYGTGIPSPPPFTSPFSPVPPSPGSQSLSHSSLHGSQMNLANQGIMGSMGGQYGPVMNPQMQHNAFQFANSGMSQQSDPGFTGATTPQSPIMSPRMGHIQSSMMQQSQANPAYQSELNGWAQGNPAGNSMFSQQSPPHFGQQSGTSMYNSNNMNISVSMAANGNGMNNMNQMTGQINMTSVTSVPTSGLSSMGPEQKYC

ncoa2

Nuclear receptor coactivator 2

1505 amino acids

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (By similarity). Has a role in primitive myelopoiesis in the differentiation of granulocytes and macrophages. May play a role in the positive regulation of the circadian clock (By similarity).

Belongs to the SRC/p160 nuclear receptor coactivator family.

161.793 kDa

MSAVGENSSDPARSEAQKRKEGPSDLLGPSPKRSTEKRNREHESKYIEELAELIFANFNDIDNFNVKPDKCAILKETVKQIRQIKEQEKAAAANEDEVQKADVSSTGQSVIDKDALGPMMLEALDGFFFVVNMEGNIVFVSENVTQYLRYNQEELMNTSVYSILHVGDHAEFIKNLLPKSHVNGVPWSSENPRRNSHTFNCRMLVNPHSEAEETQDHEAQQKYETMQCFAVSEPKSIKEEGEDFQSCLICVARRVPMKERPMLPTQESFTTRQDLQGKITSLDTSLLRASMKPGWEDLVRRCIQRFHLQNDGDISFAKRHQQEVIRHGQAFSPIYRFSLSDGTIVSAHTKSKLVRSSSTNEPQLYMSLHILQREQPVCGMASDLGNAQTMGKPMNPMSSPNTAGSSCTPQGQDATISSNTSTFPSPGAQKEPGAMHRFGCPGTMSHSATMQAATPQGSGYPLKLSSPSQGSPGMLSPRHRASPGVAGSPRLPPPQFSPAGSLHSPASMCTSSTGGNGGAGANHGYTSSSLNALQALSECHGVSHGQSLGSPDRKLGSPAAHSVAVSHHLINKMSVPESFGEQNQSEQGTPGQDEGIDLPRDEKGNLGQFGNLDGSDPQSRLRDNKSHTKLLQLLTTKTEPIESTSPPPMAGGEPGCKDGGAGNGGMGSQGGNGSHATSLKEKHKILHRLLQNSSSPVDLAKLTAEATGKELCQDSAGGTAGVPELAIKQEPVSPKKKDNALLRYLLDKDDNVLKGKGIKMEPGEIKEEGGKMTGIKTEKTDGGYDRVEPSSELDDILDDLQNSQPGLFTDSRPVSLPSAVDKQSIINDILQMTGESGANMSPQQQRALQTAVSQQNFPAPRPGQPGRAPPVRSVSLDMNMPPKGAQGQYPMMRNNNPYSIMQQQGMMGNHAVMPNQPNMVNAGVMGNNGPRVGMQQDGWGAQGTVGSAASPATAAPAGQHSLPQGALHSRMVPNPATGMPMRPNSQPGPRPMLQPQMMANAQSNMDMGMAGHQFPQQQAPPNQTAPWPDSVMPIEPVPFGNQSSSMYGGSQEDVLCPPASEGPADEGALLSQLYSALKDFDGLEEIDRALGIPALVGQAQPVEQDQFPGQDPSMMMDQKPPMYGQQQYASSPANMQQAGYTPMQDATFHGLQGQMGQRPGYPMLRMQARPGLRPGGVVPNQPNTLRLQLQHRLQAQQNRQPMMNQMGGVSNMNLPLRPNVPNQGTINAQMLAQRQRELLSNHLRQRQLDQQRQQQQQQQQQRSLAMRAQGLTMPPNMAAAAAGMPGAMSNPRIPQANLQQFPYPPNYGTGLASPPPSTSPFSPGSPNLPAPQLLSHSAMHGSQMSLANQGMLGSLSGQFGAVMSPQMQHSAFQFPSSGMSQQSDGGFGGAATPQSPLMSPRMGHAQSPMMQQAQGNSSFQSSPDMNGWPQGNINTNSMFTQQSPPQFSQQANNNMYNGNGMNLNVSMAANSSNMGQMGNQMSMSSMNSGPGSGMANMGPEQQKYC

Ncoa2

Nuclear receptor coactivator 2

1465 amino acids

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer.

Belongs to the SRC/p160 nuclear receptor coactivator family.

159.436 kDa

MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMVNGGSWTGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDKQSCLICVARRVPMKERPALPSSESFTTRQDLQGKITFLDTSTMRDAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISIHMLHREQNVCVMNPDLTGQAMGKPLSPMSSSSPARQAMCSGNPGQDVALGSNMNFPMNGPREQMSMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGLNPGQPSSVLSPRHRMSPGVAGSPRVPPSQFSPAGSLHSPAGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGPSLASPDLKMGNSQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAQASCHPEEQKRPNDSSMPQAASEDRAEGHSRLHESKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELNQESSGTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVTPVGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRSSMPSGEWAPQSPAVRVTCAATTGAMNRPIQGGMIRNPTASIPMRANSQPGQRQMLQPQVMNIGPSELEMNMGGPQYNQQQAPPNQTAPWPESILPIDQASFGSQNRHPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQESSMMLEQKPPVFPQQYASQTQMAQGSYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQPLMNQISGVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPTGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQPASDINGWAQGSMGGNSMFSQQSPPHFGQQANTSMYNNNMNINVSMATNTAGLSNMNQMTGQMSMTSVTSVPTSGLSSMGPEQVNDPALRGSSLFTTNQLPGMDMIKQEGDGSRKYC

NCOA2

Nuclear receptor coactivator 2

1464 amino acids

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Belongs to the SRC/p160 nuclear receptor coactivator family.

159.157 kDa

MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC

Ncoa2

Nuclear receptor coactivator 2

1462 amino acids

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (PubMed:24529706).

Belongs to the SRC/p160 nuclear receptor coactivator family.

158.466 kDa

MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMVNGGSWSGEPPRRSSHTFNCRMLVKPLPDSEEEGHDSQEAHQKYEAMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPTLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQAMGKPLNPISSSSPAHQALCSGNPGQDMTLGSNINFPMNGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQASSVLSPRQRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAEASCHPEEQKGPNDSSMPQAASGDRAEGHSRLHDSKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESSSTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVPPAGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRPSMPSGEWAPQSPAVRVTCAATTGAMNRPVQGGMIRNPTASIPMRANSQPGQRQMLQSQVMNIGPSELEMNMGGPQYNQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDAEQFSSQESSIMLEQKPPVFPQQYASQAQMAQGGYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQPLMNQISSVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMQQQVQQRTLMMRGQGLNVTPSMVAPAGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQPTSDMNGWAQGSMGGNSMFSQQSPPHFGQQANTSMYSNNMNISVSMATNTGGLSSMNQMTGQMSMTSVTSVPTSGLPSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDASRKYC

ncoa2

Nuclear receptor coactivator 2

1440 amino acids

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required in a nuclear receptor pathway to suppress expression of dorsal mesoderm genes. May play a role in the positive regulation of the circadian clock.

Belongs to the SRC/p160 nuclear receptor coactivator family.

157.293 kDa

MSGMGENPSDPSRAEPRKRKESIDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNLNFKPDKCAILKETVKQIRQIKEHEKTAAANEDEVQKADVSSTGQSVIDKDALGPMMLEALDGFFFVVNREGNVVFVSENVTQYLRYNQEELMNTSVYSILHVGDHSEFIKNLLPKSIVNGGPRRNSHTFNCRMLVKPMMECEEEGHDGQETHQKYETMQCFAVSQPKSIKEEGEDFQSCLICVARRVPMKERPVPPPSESFTTRQDLQGKITSLDTTNMRALMRPGWEDLVRRCIQRFHSQHDGEISYSKRHHQEVLRQGHATSPFYRFALSDGTTVLAHTKSKLMRSQTTNEPQLVLSLHVLQREQNMCGLNQDLAGQAMGKTLNPVQSSSPAHQAMYGGNPGQDTTISSNMNYAITGPKEQMGMAAGRFVGSGGMNHISSLQATTPQGNNYALKINSPSQGSPGMGQGQPNSMLSPRHRVSPGVAGSPRIAPSQFSPAGSLHSPVSVCSSTGNSHSYTNSSLNALQALSEGHGVPLAPPLSSPDLKVGNVQHSPVNMNPPQLRKMGSIDSKESFGLYGEQPESAAGQGESGCHSNEQKDCSENLSSVGDQTEGQSRLLDSKGQQKLLKLLTTKSDQMEPSPLPSNTLGDMNKDSLSNFASNSMSASAHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESNSTGPGSEVTIKQEPVSPKKKEHALLRYLLDKDDTKDNVADITPKLERPDVKVEPTSCPKLLSVKAEKEEPSFGHSDQLMPPGSDLDNLDEILDDLQNSQLSQLFPDARHDGSNSADKQAIMNDLMQLAGDNSTGLPAGAHKQRMIRIQQNNGFSSQLAAQLGRLPNQSLPLDINLQSQVSAGSFPPMRNSAPYTTVSQSVVMNNQAMMGSQGNVSNSSPGIIGVNGPRPALKPGDWGSQASAVRPACPTPSTAINRPIQDLTRSPTASIPMRPGGQVCPRQVLQSPVINMGSSELDMNIGGPQYTQQQAPPNQTAPWPDSILPIDQPSFNNQNRQPFGSPADDLICQPIASQSPTDDGNLLDQLYMALRNFDGLEEIDRALGIPEMVSQGQAVEQESFVSPESNLMMEQKPPLYNHAYANQGQMAQNSYTPMQDPGFNPMGQRPSYGILRMQNRPGLRPTGMVQNQPNQLRLQLQHRLQAQNRQPIMNPINNVSNMNLAMRPGVPGQLREQGPINAQMLAQRQRELLSQHLRQKQLQQQQQQQQQQQQQVQQHRAMMMRGQGLAMPPNMVGSGGIPASINSPRIPQGNTQQFPFPPNYGMSQQSDPGFTGATTPQSPIMSPRMGHIQSPMMQQSQASPAYQSELNGWAQGNPAGNSMFSQQSPPHFGQQSGTSMYNSNNMNISVSMAANGNGMNSMNQMTGQINMTSVTSVPTSGLSSMGPEQKYC