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ncl-1

Gene
ncl-1
Protein
B-box type zinc finger protein ncl-1
Organism
Caenorhabditis elegans
Length
851 amino acids
Function
Translational repressor that inhibits protein synthesis (PubMed:9508766, PubMed:26492166). Represses the translation of mRNAs such as fib-1, probably by being recruited by RNA-binding protein nos-2 and the Pumilio proteins puf-5, puf-8 and puf-9 to the consensus core PUF binding motif in the 3'-UTR of fib-1 mRNA (PubMed:26492166). Negatively regulates ribosomal RNA (rRNA) synthesis, ribosomal protein synthesis and nucleolus size (PubMed:9508766, PubMed:8582642, PubMed:22768349, PubMed:26492166, PubMed:28853436). Its role in the negative regulation of nucleolus size is most likely through its negative regulation of the translation of proteins such as the rRNA 2'-O-methyltransferase fib-1, and dao-5 (PubMed:26492166, PubMed:28853436). Might act directly as a transcription factor to inhibit RNA polymerase I (rRNA) and III (5S RNA) transcription (PubMed:9508766). Plays a role in embryonic development, and in particular, is involved in regulating the localization of proteins, such as par-2, that are required for embryonic cell polarity (PubMed:18652816). Plays a role in the regulation of lifespan, and the response to nutrient availability (PubMed:28853436).
Mass
91.955 kDa
Sequence
METQLSVQLGLDSLLTDFGLESVMNKQQQLFANMGLSDIGAPTPSTAIPVPNAHLHPSMVAGSDPSNPVVGFGFGSPSSTTSSSPPLSNSPTIEQQQHAQLTAMMQGIMSNNNVAVSNGSGVQVASVPAVHCSGCKSNETATSFCQDCNANLCDNCTMAHKFMHCFADHRVVSLTTPGTGSSSSSTSSSSSASSTSSHQVPSLGGKQSPDSMMLGSGKRSVLCLQHRASELVFFCVSCNLAICRDCTVSDHPSGTHQYELIADVADKQMLKMEQLIADARSKHADMLDMFKQVDNKQQVLTASLHNAHAQLEETVSNLINVIQDQKKTLAKDIDNAFAAKQIQLTMVDKRIQSMADKLSQTIEFSRRLMSFASPAEVMVFKQLLDTRLQLFLGFNPDTSGVLMTPCEIEYLGAAGLFNNSASTVSQLLGSVHGGSPINNAPAANDFLMPQAGLAPIGRAQSRIIPIEQNQLARSPPHHIAGSLPMNAYSDSNLLRPNKDFGGSSQSLGPFNPLGASVPGAAADPFSSQYDKWSLGVEPSVGGLLEGGNVDEEKFQTLFPPSRSQIKRQKMIYHCKFGEFGVMEGQFTEPSGVAVNGQGDIVVADTNNHRIQVFDKEGRFKFQFGECGKRDGQLLYPNRVAVNRTTGDFVVTERSPTHQIQVYNQYGQFLRKFGANILQHPRGVCVDSKGRIIVVECKVMRVIIFDMFGNILQKFSCSRYLEFPNGVCTNDKNEILISDNRAHCIKVFSYEGQYLRQIGGEGVTNYPIGVGINSLGEVVVADNHNNFNLTVFSQDGTMIGALESRVKHAQCFDVALVDDGSVVLASKDYRLYLYRFLPATSGQSTSSASSQI