Protein
Nickel-cobalt-cadmium resistance protein NccA
Organism
Alcaligenes xylosoxydans xylosoxydans
Function
Component of the NCC cation-efflux system that confers resistance to nickel, cobalt and cadmium. May form a membrane tunnel, which allows ion transport across the membrane.
Similarity
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
Sequence
MIESILSGAVRFRWLVLFLTAVVGAIGAWQLNLLPIDVTPDITNKQVQINTVVPTLSPVEVEKRVTYPIETAIAGLNGVENMRSLSRNGFSQVTVIFKESSNLYFMRQQVTERLAQARPNLPAGVEPQMGPVSTGLGEVFHYSVEYEFPDGKGAKVKDGEPGWQSDGSFLTERGERLTDRVSKLAYLRTVQDWIIRPQLRTTAGVADVDSLGGYVKQFVVEPDAAKMAAYGISFEELAQALEDANLSVGANFIRRSGESYLVRADARIKSADEIARAVIAQRQGVPITVGQVANINVGGELRSGAASRNGYETVVGSALMLVGANSRTVAQAVGDKLEEIKKTLPPGVVIVPTLNRSQLVMATIKTVAKNLVEGAALVVVILFALLGNWRAAVIAALVIPLSLLISAIGMNGLNISGNLMSLGALDFGLIIDGAVIIVENSLRRLAERQHHEGRLLTLKERLEEVILSSREMVRPTVYGQLVIFMVFLPCLTFQGVEGKMFSPMVITLMLALASAFVLSLTFVPAMVAVLLRKKVSEKEVRVIAVTKERYRPLLERAVARPMPFLGAALVTLALAAMAFTFVGREFMPTLDEQNLNLSSVRIPSTSIDQSVAIDLPLERAVLSLPEVQTVYSKAGTASLAADPMPPNASDNYIILKPKSEWPEGITTKEQVIERIREKTAPMVSNNYDVTQPIQMRFNELIGGVRSDVAVKIYGENLDDLASTAQKIAAVLRKTPGATDTRVPLTGGFPTFDIVFDRAAIARYGLTVKEVADTVAAAMAGRPSGQIFDGDRRYDIVIRLPGQQRENLDVLGALPVMLPAVEGQPRASVPLRQLVQFRFTQGLNEVSRDNGKRRVYVEANVGGRDLGSFVDDAAKRIAAEVKLPPGMYIEWGGQFQNLQAATQRLAIIVPLCFILIAATLYMAIGSAALTATVLTAVPLALAGGVFALVLRDIPFSISASVGFIAVSGVAVLNGLVLISAIRKRLEDGAAPNEAVIEGAMERVRPVLMTALVASLGFVPMAIATGTGAEVQKPLATVVIGGLITATVLTLFVLPAVCGMVLRRQKKLEKPGGELLEA