NCAPD2

Condensin complex subunit 1

1401 amino acids

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).

Belongs to the CND1 (condensin subunit 1) family.

157.182 kDa

MAPQMYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDIRHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREATGHFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYLQDAYSFSRKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGLDEKFPQDYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTSSETTMEEELGLVGATADDTEAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFSAFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPSTGSRYQPLASTASDNDFVTPEPRRTTRRHPNTQQRASKKKPKVVFSSDESSEEDLSAEMTEDETPKKTTPILRASARRHRS

Ncapd2

Condensin complex subunit 1

1392 amino acids

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.

Belongs to the CND1 (condensin subunit 1) family.

155.665 kDa

MSPHNFEFHLPLSPEELLKSGGVNQYVVREVLPVKHLSSQLRAFQSAFRAQGPLAILEHFDTVYSILHHFRSIEPGLKEDTLEFLKKVVSRHSQELSSILDDAALSGSDRSAHLNALKMNCYALIRLLESFENMTSQTSLIDLDIGGKGKRARAKATLGFDWEEERQPVLQLLTQLLQLDIRHLWNHSAIEEEFVSLVTGCCYRLLENPTISHQKNRSTKEAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHLPPVLVTAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDTAGAKGFAAFLTELAERIPAVLMANMCILLDHLDGENYMMRNAVLAAIAEMVLQVLNGDQLEESARETRDQFLDILQAHGHDVNSFVRSRVLQLFARIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDIDLAGPLQKEIQKLQEMRAQRRSAAATAALDPEEEWDAMLPELKSTLQQLLKLPQEEGDHQIADAETAEEVKGRIRQLLAKASYKQAIVLTREATSHFQESEPFSHTEPEENSFLNLLGLIFKGPEASTQDSHGDTDPGLTGSKDSPSVPEPEGSQSNDELVKQEMLVQYLQDAYGFSQKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQTLIHNLSLLLVDASVGTIQCLEEILCEFVQKDEVKPAVIQLLWERATEKVPSSPLERCSSVMLLGMMARGKPEIVGSNLDALVRVGLDEKSPQDYRLAQQVCLAIANISDRRKPSLGERHPPFRLPQEHRLFERLQDMVTKGFAHPDPLWIPFKEVAVTLTYQLAESPDVLCAQMLQGCAKQVLEKLEKNATEADPKETAPRLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELGRRRVLREEQEHRAKEPKEKTASSETTMEEELGLVGGATADDTEAELIRSICEKELLDGNQVLAAFVPLLLKVCNNPGLYSNPELCAAASLALGKFCMISAPFCDSQLRLLFTMLEKSSLPTVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPEGGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQYRDLAYCMSQLPLTERGLQKMLDNFECFGDKLLDESVFSAFLSIVGKLRRGAKPEGKAIIDEFEQKLRACHTRGMDGIEEFETGQGGSQRALSAKKPSAVSRLQPLTSVDSDNDFVTPKPRRTKPGRPQTQQRKKSQRKAKVVFLSDESSEDELSAEMTEEETPKRTTPIRRASGRRHRS

ncapd2

Condensin complex subunit 1

1364 amino acids

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.

Belongs to the CND1 (condensin subunit 1) family.

154.191 kDa

MTFHFHIPLAFRDLLKSGGIGQYVVQEVLPVRHVDAQFAAFQTSFRTEAPLCILQHFDTLYSILHHFRSLDIAIKEDVLEVMVKVASRHANELPAILEDLNLSVPQRAAHLNALKMNCFILTQLIEAFEAETYKASLGSVEPSGKGKKAKSKPEGFSWESERESILQALTHLLQLDIRRLWSMSVVEEEFVSMMTSCCYKMMENPNIVMAKNKSTREALGHLLGVTVKRYNHMLSASVKVIQLLQHFEHLASVLVHTVSLWATEYGMKPVIGEIMREIGQKCSQDLSRESSGFKAFATFLTELAERIPAIMMPSISVLLDYLDGENYMMRNSVLTVMGEMVVRVLSGDQLEEAEKSSRDQFLDTLQEHLHDVNTYVRSCVIQIYNRIVQEKALPLSRFQSVVTLVVGRLFDKSVNVCKNAIQLLASFLANNPFTCKLSSVDLKVPLEKETKKLKEMREKYQGPKPVVVISPEEEWEAMLPEVLEAFKILQQESKEEEDIETEEIESSQHLREQILILLRKTSYKNSIRLTQKGIERFQEDPLFSEGDSEAKSELGILEKIFTEKKADLEQPTTKDQDDAQVNPTSEELPSQEVQNSDMDKQEMLVQYLSDAHHFALKIEEAIDVISKMMYETAVSVVQEVIEFFVTVSQFGVSQALLGVRRMLPLVWSKEPGVREAVLSAYRRLYLSSNGESERVKAQALVRSLSLLMVDSSAGILQCLEEIVSEFVQKGDIHPSVIQLLWEKFTQKSPCSEFERRAAVMLLGMMTRGQPEIVMSNLDTLVSVGLGEQVQKDYQLAREVCNCILKITDSQKQTLGKSTEPFRLPKDHSLFVCLTEAVAGGIGLSGLHWLPFKETAVRLVYELGEEPEEICSEILLRCSQNVLDGHQTQDEVPNVPAFLLTHLLSLAGDVALQQVVHLERAVSAELRRRRVLKEEQEAEKVGKQRKSKANESTMEEELGLVGASADDIEAELIRKICDTELLGGQQYLSAFLPLILRICNNPGRYSDPDLCTVATLALAKYMMISSDFCDTHLRLLFTLLEKSPLPSVRSNIMIALGDLSIRFPNLIEPWTPNLYARLRDPSREVRKTAGMVMTHLILKDMVKVKGQVSEMAVLLIESDQEISALARNFFNELSNKGNAVYNLLPDIISRLSDPDCGVEEEAFRTIMKQLLSYITKDKQTESLVEKMCHRFRTARTERQWRDLAHCLSLLPFSEKGLRKMQDCFDCYGDKLSDEAVYNSFLTTVAKMRRGAKPELKALIDEFEQKLSRCHNKGLENMDVPEEPSAESDAQPPKAKRPPLASVNVKKGKSEDDFQTPKPPASRKSRRKVAVNFSSDEESDLEAELSEAETPKNPTPIRRTARSRAK