Protein
Nitrobenzene nitroreductase
Organism
Pseudomonas oleovorans
Function
Involved in the biodegradation of nitroaromatic compounds (PubMed:8368838). Catalyzes the two-electron reduction of nitrobenzene (NB) to produce a nitrosobenzene (NOB) intermediate, which is immediately reduced to hydroxylaminobenzene (HAB) by a second two-electron transfer (PubMed:7601851). Also active on menadione and nitrofurazone (PubMed:7601851). Replacing NADPH with NADH results in a 4-fold decrease in the reaction rate (PubMed:8368838).
Similarity
Belongs to the nitroreductase family.
Sequence
MPTSPFIDDLIRDRRAKRGFLDQPVSIEMVKDILSAAKYAPSSSNTQPWRCYVITGEARERITTAAVEAYRAAPEGLPPEYPFFPQPLHEPYATRFNSFRGQLGDALGIPRSDITLRRRDVERQFRFFDAPVGLIFTMDRRLEWASFICYGCFLQNIMLAAKGRGLDTCTQVFWSMQHPVLRTELNLPDDQMVVAGMSLGWADNSLPENQMSISKMELEEFTTFVHE