Protein
NGFI-A-binding protein homolog
Organism
Drosophila melanogaster
Function
Transcriptional regulator that can both act as a coactivator or a corepressor depending on the context. Lacks DNA-binding domains and acts by associating with other transcription factors such as rotund (rn) and squeeze (sqz). Acts as a coactivator of sqz and is required to limit the number of neurons that express the LIM-homeodomain gene apterous and to specify Tv neuronal fate. Acts as corepressor of rn in wing development and is required to limit the expression of wingless (wg) in the wing hinge, where wg plays a mitogenic role.
Similarity
Belongs to the NAB family.
Sequence
MEASSNPTTPTTAVATTTSTSSPSPAASTSSKGHSQSATASASASATQSQLLTTSLEMPKTEDLYNLSVASGLSEGQRSLSGAPSASSSPIMSPQGKIFGRNANGTMITTSRPGNEAEVQLYRVLQRASLLAYYDTLLEMGGDDVQQLYDAGEEEFLEIMALVGMASKPLHVRRLQKALHEWANNPGLFQGPMMPHLGLCETPPKPALIFNPDTTPALPRQKFPSFNPSGSSFMPSPVPPAPLPASASVPAPTVPLATQISCPSAPSVPLPLVLPPNPLTSSPHPSANSNLPANTAHQVSSSSPQLTPVLTEAQIQRITMCADKIGRQLPQREPRAQTTRKRTTRELEQVIAMGEQDPRRMDEIRKYSAIYGRFDCKRRPEKPLTLHEVCVNEAAAQLCRNPQTIWLLTRRDELFPLARQIVKDAGFGHSASIARYGGLLTQLPSQGAGLGGGRAPGDTDCESSDAAVPSKRQRLSSTEAAQLPLDLNREAVEDSRYNLFAMYQKFAKPPFDLSEIAKFSVSKAADYEDNDSRFSFSNSSSPTMPTPCNGMEGERSPVSRQMETSSPPRESVDLSGTSSGAALSGVQVISAAGDNIIAVANPALALSPALNEVLALKRSAASPET