Protein
Myosin-J heavy chain
Organism
Dictyostelium discoideum
Function
Processive motor protein that can move over long distances along F-actin without disassociating; processiveness depends on high physiological Mg(2+) concentrations. Presents a high actin affinity in the presence of ADP, fast ATP hydrolysis, and a high steady-state ATPase activity in the presence of actin that is rate limited by ADP release. Physiological decrease of free Mg(2+) ions leads to an increased rate of ADP release and shortening of the fraction of time it spends in the strong acting binding states.
Similarity
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Sequence
MTTSTIENGASSPIIVSSSTPKLYQEGAGVWIPDQELGWIGADVIEHSETSADQVLVRTEDDREVKIPLSKVFQKNPDILEGVDDLSFLSHLHEPAILHNLHHRYNLNQIYTYIGKILIAINPYTSLPLYGKEMISAYYGKQLGTLAPHVYAVAEDAFKDMRYDGTSQSILVSGESGAGKTETTKFLLQYFAAMGNMIKESTSSSSINGINTSSDGIPVTPPPSPMKKSPVDKSVEERVLESTPLLEAFGNAKTLRNDNSSRFGKFIEIHFNEMGSIIGAKILTYLLEKSRIVRQVYNERNYHIFYQLLSGASEELKEKLNLKTIEEYSYLNKSGCFEIEGVSDEEHFNKTCHAMQVAGITLVEQENVFRILSAILLIGNFEFENIAGSNDDSCQLIDRDPLEKVSVLLGCAQPDELLNSMLTRKVVTGKESYISHNTKERAENARDSLSMFLYGMMFDWLVVKINSSMSISTQQKSKSFIGVLDIYGFESFEVNGFEQFCINYANEKLQQLFNQHVFKEEQQEYIKEKIDWSYIDFNDNQDTLDLIEKKPICILTLLDEETMFPKATPQTLATKLYSKMTSHSKFEKPRFSSTAFTINHYAGKVTYETDQFLDKNKDFIIPEQISILQRSNFSFIKVLMSHSDKFTQSPGGHPQGNGGPTSSNTKGTSGSSSMKFLSVGSQFSTSLATLMKTISTTTPHYVRCIKPNPEKLPQTFNKQDVIHQLRCGGVMESVRICCAGFPTRRLLSEFYQRYKILYVKDINTGSGGGKKGSNNNKIKDPKILVQNLLTGIELSDDKYKIGLTKVFLRAGQLASLEDMRLEQLDRSATVIQKRWKGYLYRKRYKQLRDASLIIQTKLRSVHAKQQLSALQRTHSAILIQKVWRAHRDRVQYQKIRDASLQLQTVMRRHLFSEQVHRERCENAAIILQTKIRQILSKREVDKKLRGIILIQARWRMKLAKRVYIQLRAEARSLRTVQEQKNKLQEKLEELQWRLTSEAKRKQQLEDQKVKSDTTISELSSNNDHLELQLSEIQLKYQELDKSNQSSQLQLSECLSKLEEQTQQLDHSSKLNKKLEKDLSDQHDSIEKLQSQFNETEQQLQQFKQQSEELSSKLSKTTQQLDFNKQEFDRLSQERDTDNTNNQLEIQQLKKANSTLEEDYFSLSGIRDNLERQVLELRDENQLIKERLDSLGQQSSQFQSGAALEKQQLEQLVQEQSEQLIKLSSEKLGSEEEAKKQINQLELELTDHKSKLQIQLQLTEQSNEKIKKLKGKLEEYQDEKKQLQQELERIKQSKQSVEDEKNSLITQLTTVKFESTQVSTNVSHQKEKITTLKSTIEELNKSIGKLQAEQKNKDDEIRKIQFELNDQKQQFTRQTKEFSDLQSQQSIDRQKSEITIHSLERTNETLKSDFERVQQSLKQQERDCQQYKDTINRLENEVKQLTQLKERFENEFFVAKEQNSNQTQESVYLKEVTTQMQQNQSRIERELEEKKQHITRIDDERDELKKQLTQLQQQHEQSSTQLLLAQNELERLRKKELKYKERGHETSKQQDQFNMEIQSLRITNNDQLKSLQDYEQEKKKLKDKLSSSKQEAQQQRESIIKMDAELSAIKQHSQWVENSFTDMKQRNQELIESSALYKQQLLQQTSTIDSTIKEKENEISKLQQQLETSNQQLHQLKEELNSMKQSNQLESTEQSKQLNQLIQENQQLKSVTNEISKQLDDAVFENQKINNTIKEQEIKSKRMSVELQQHIDEGKQQEIQQLQSTIAQLKQQQQSETDRLEKEIQQMKRERETQMKLVESTKLNYHMLEDRMELYRNVMEIIDYKETEWEKLARLAGCKELDTKLLSDFLLSCKLEHTSLGSQMWFHQIDYWCPYERDSSKGIFYGIIRSIVDFTIKNFDDVDLLSYLLACCSLTLFLYKKNLVKHLNGANSIMPIIPTLGDLEELNERLSHQSLTTSGKFSGGGGGGGIDFIDQLQQSTGITFGLIFKATTLKLSPLVDGAILNENYNKKLTSISASSFGSGSFGLGSNGVGSVLSIELITTYLSSIITIFQHRMVHFTLSQRFFNQVFCWIGALIMKGFMLRQTFCTETFATFVKTKIDFLTRWADDIGNVWVGDVANAFQQVREVINVLNIKDKEKIIDDKIRKQYCPTLNSNQLKQVLSLFSPGEFGGKRVSAKVIASICPPNKSSAGQSFVQDENKLNTIPIDSLHYLEIQDIKTLSLPLSIRQTIETEIINLKQQIACKK