Protein
Myosin IB heavy chain
Organism
Dictyostelium discoideum
Function
Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin IB may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the whole cell motility of aggregation-stages cells. Overexpression results in significant decrease in the rate of cellular translocation and fluid-phase pinocytosis and abnormalities in the normal rearrangement of the actin cytoskeleton.
Similarity
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Sequence
MSKKVQAKQGTDDLVMLPKVSEDEICENLKKRYMNDFIYTNIGPVLISVNPFRNLNNSGPDFIEAYRGKHAQEVPPHVYQLAESAYRAMKNDQENQCVIISGESGAGKTEAAKLIMGYVSAISGSTEKVEYVKHVILESNPLLEAFGNAKTLRNNNSSRFGKYFEIQFDKAGDPVGGKIYNYLLEKSRVVYQNPGERNFHIFYQLLAGASAQEKRDYVLSSPESYYYLNQSQCYTVDGINDVSDYAEVRQAMDTIGLTAQEQSDIIRIVACVLHIGNIYFIEDDKGNAAIYDPNALELAASMLCIDSATLQNAILFRVINTGGAGGAGNRRSTYNVPQNVEQANGTRDALARTIYDRMFSWLVERVNQSLSYYKSPYQNVIGILDIFGFEIFEKNGFEQFCINFVNEKLQQFFIELTLKAEQEEYVREGIKWEPIKYFNNQIVCDLIEGKSPPGIFSLLDDICSTLHAQSTGTDQKFLEKMAGIYDGHLHWRGMTGAFAIKHYAGEVTYEAEGFSDKNKDTLFFDLIEAIQCSKMPFLASLFNEDTGSLQKKRPTTAGFKIKTSAGELMKALSQCTPHYIRCIKPNETKKAKDWENSRVKHQVQYLGLLENVRVRRAGFAYRNTFDKVLKRYKKLSSKTWGIWGEWKGDAIEGCKTIFQDMNLEAGQWQLGKTKVFIRHPETVFLLEEALDKKDFDCTAKIQKAFRNWKAKKHSLEQRAQIAHMFKDKKERQRNSIDRKFTSDYIDFENQFGLQEAMQNAHKKERVVFADTVIKIDRRAKQKNYEMVLTDQALYFVEKSIKKKVLVHTLIRRVGLREIKGVSISTLSDNVIVFHLPEHDQVIENDKKTEIIIVLVEYFKAIGGGSLNVQFSDRINYTLKKGEQKEISFQKSEQCPTLVVKKGGKGLIGTIASGLPSSTDSTPKNYNPNSMSQASSRPAPQQSAGRGRGMPQGAGQPQPQQPQQQQRPMPQPQQGGGARPMPQPQQGGGARPMGAPQQGGAPQQGAGRQLPQPTQQGGAPGGRGAPMGRGAPGGGPAGAGGRPLPTVAKPAPQPSRPTAKALYDYDASSTDELSFKEGDIIFIVQKDNGGWTQGELKSGQKGWAPTNYLQYN