mycP1

Gene

mycP1

Protein

Mycosin-1

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

449 amino acids

Function

May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB.

Similarity

Belongs to the peptidase S8 family.

Mass

46.454 kDa

Sequence

MQRVAVMVLAVLLALFSAPPAWAIDPPVIDAGAVPPDETGPDQPTEQRKICATPTVMPNSNFADRPWANDYLRIQEAQKFATGAGVTVAVIDTGVNGSPRVPAEPGGDFVDAAGNGMSDCDAHGTMTAAIIGGRPSPTDGFVGMAPDVRLLSLRQTSVAFQPKGARQDPNDPNTTQTAGSIRSLARSVVHAANLGAQVINISEAACYKVTRRIDETSLGAAINYAVNVKGAVIVVAAGNTGQDCSQNPPPDPSVPSDPRGWREVQTIVSPAWYDPLVLTVGSIGQNGQPSNFSMSGPWVGAAAPGENLTSLGYDGQPVNATPGEDGPVPLNGTSFSAAYVSGLAALVKQRFPDLTPAQIINRITATARHPGGGVDNYVGAGVIDPVAALTWEIPDGPEKAPFRVKEVPPPVYIPPPDRGPITAVVIAGATLAFALGIGALARRALRRKQ

Protein

Mycosin-1: mycP1

Gene

mycP1

Protein

Mycosin-1

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

446 amino acids

Function

May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice.

Similarity

Belongs to the peptidase S8 family.

Mass

45.118 kDa

Sequence

MHRIFLITVALALLTASPASAITPPPIDPGALPPDVTGPDQPTEQRVLCASPTTLPGSGFHDPPWSNTYLGVADAHKFATGAGVTVAVIDTGVDASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIAGRPAPTDGFVGVAPDARLLSLRQTSEAFEPVGSQANPNDPNATPAAGSIRSLARAVVHAANLGVGVINISEAACYKVSRPIDETSLGASIDYAVNVKGVVVVVAAGNTGGDCVQNPAPDPSTPGDPRGWNNVQTVVTPAWYAPLVLSVGGIGQTGMPSSFSMHGPWVDVAAPAENIVALGDTGEPVNALQGREGPVPIAGTSFAAAYVSGLAALLRQRFPDLTPAQIIHRITATARHPGGGVDDLVGAGVIDAVAALTWDIPPGPASAPYNVRRLPPPVVEPGPDRRPITAVALVAVGLTLALGLGALARRALSRR

Protein

Mycosin-1: mycP1