Protein
Mycinamicin VIII C21 methyl hydroxylase
Organism
Micromonospora griseorubida
Function
Involved in the biosynthesis of mycinamicin, a 16-membered macrolide antibiotic. Catalyzes hydroxylation at the C21 methyl group of mycinamicin VIII, the earliest macrolide form in the postpolyketide synthase tailoring pathway, leading to mycinamicin VII. Uses ferredoxin MycCII in electron transfer for catalysis.
Similarity
Belongs to the cytochrome P450 family.
Sequence
MVVWPMDRTCAWALPEQYAEFRQRATLVPAKVWDGSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMFISAFSVRQVETMRPEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLLGVPYEDREFFQERSELASRPNDDRSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQPELMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPIFGIDELLVEW