Mybbp1a

Myb-binding protein 1A

1344 amino acids

May activate or repress transcription via interactions with sequence specific DNA-binding proteins (PubMed:9447996, PubMed:11956195, PubMed:14744933). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (PubMed:14744933). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (PubMed:19129230). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (PubMed:19129230). Has a role in rRNA biogenesis together with PWP1 (By similarity).

Belongs to the MYBBP1A family.

152.037 kDa

MAEMKSPTKAEPATPAEAAQSDRHSLLEHSREFLDFFWDIAKPDQETRLRATEKLLEYLRTRPNDSEMKYALKRLITGLGVGREAARPCYSLALAQLLQSFEDIPLCDILDQIQEKYSLQAMNKAMMRPSLFANLFGVLALFQSGRLVKDKEALMKSVQLLKILSQHPNHLQGQPIKALVDILSEVPESMFQEILPKVLKGNMKVILRSPKYLELFLLAKQRVPTKLESLMGSVDLFSEDNIPSLVNILKVAANSVKKEHKLPNVALDLLRLALKESRFELFWKKVLEEGLLKNPSWTSSYMCFRLLGASLPLLSEEQLQLVMRGDLIRHFGENMVISKPQNLFKIIPEISTYVGTFLEGCQDDPKRQLTMMVAFTTITNQGLPVMPTFWRVTRFLNAEALQSYVAWLRDMFLQPDLNSLVDFSTANQKRAQDASLNVPERAVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIARFCLFHAFFKTKKATPQIPETKQHFSFPLDDRNRGVFVSAFFSLLQTLSVKFRQTPDLAENGKPWTYRLVQLADMLLNHNRNVTSVTSLTTQQRQAWDQMMSTLKELEARSSETRAIAFQHLLLLVGLHIFKSPAESCDVLGDIQTCIKKSMEQNPRRSRSRAKASQEPVWVEVMVEILLSLLAQPSNLMRQVVRSVFGHICPHLTPRCLQLILAVLSPVTNEDEDDNVVVTDDADEKQLQHGEDEDSDNEDNKNSESDMDSEDGEESEEEDRDKDVDPGFRQQLMEVLKAGNALGGVDNEEEEELGDEAMMALDQNLASLFKEQKMRIQARNEEKNKLQKEKKLRRDFQIRALDLIEVLVTKQPEHPLILELLEPLLNVIQHSMRSKGSTKQEQDLLHKTARIFMHHLCRARRYCHEVGPCAEALHAQVERLVQQAGSQADASVALYYFNASLYLLRVLKGNTNKRHQDGHKLHGADTEDSEDQAANCLDLDFVTRVYSASLESLLTKRNSSLTVPMFLSLFSRYPVICKNLLPVLAQHVAGPSRPRHQAQACLMLQKTLSARELRVCFEDPEWEQLITQLLGKATQTLQTLGEAQSKGEHQKELSILELLNTLLRTVNHEKLSVDLTAPLGVLQSKQQKLQQSLQQGNHSSGSNRLYDLYWQAMRMLGVQRPKSEKKNAKDIPSDTQSPVSTKRKKKGFLPETKKRKKLKSEGTTPEKNAASQQDAVTEGAMPAATGKDQPPSTGKKKRKRVKASTPSQVNGITGAKSPAPSNPTLSPSTPAKTPKLQKKKEKLSQVNGATPVSPIEPESKKHHQEALSTKEVIRKSPHPQSALPKKRARLSLVSRSPSLLQSGVKKRRVASRRVQTP

Mybbp1a

Myb-binding protein 1A

1344 amino acids

May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (By similarity).

Belongs to the MYBBP1A family.

152.286 kDa

MAEMKSPTKAEPASPAEAPQGDRRSLLEHSREFLDFFWDIAKPDQETRLRATEKLLEYLRTRPSDSEMKYALKRLITGLGVGREAARPCYSLALAQLLQSFEDIQLCDILGQIQEKYNLQAMNKAMMRPTLFANLFGVLALFQSGRLVKDKEALMKCVRLLKILSHHYNHLQGQPVKALVDILSEVPESMFQEILPKVLKGDMKVILSSPKYLELFLLARQRVPAELESLVGSVDLFSEDNIPSLVNILKVAANSVKKEQKLPDVALNLLRLALQENKFERFWKEVLEEGLLKKPSYTSSYMCFRLLGASLPLLSDEQLQLVMRGDLIRHFGEHMVVSKSQNPLRFIPEISAYVGTFLEGCQDDPKRQFTVMVAFTAITNQGLPVMPTFWRVTRFLNTEALQNYVTWLRDMFLQPDLDSLVDFSTANQKRVQVASLNVPERTVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIARFCLFHAFFKTKKATPQIPETKQHFSFPLEDGNRGVIVSAFFSLLQTLSVKFRQTPDLAENGKPWTYRLVQLADMLLKHNRNVANVTPLTAQQRQAWDQMMSTLKELEAQSSETRAIAFQHLLLLVGLHLFKSPAESCDVLGDIQTCIKKSMEQNLRRSRSRAKASQEPVWVEVMVEILLSLLAQPSNLMRQVVRSVFGHVCSHLTPRGLQLILAVLNPETNEDEEDNVVVTDTDEKQLKHGEDADSDSEDSKNSESDVDSEDGEESEEEDRDKDVDPGFRQQLMEVLQAGNALGGEEEEEEELGDEAMMALDQNLASLFAEQKMRIQARHEEKNKLQKEKQLRRDFQIRALDLIEVLVTKQPEHPLILELLEPLLNIIQRSMRSRGSTKQEQDLLHKTARIFMHHLCRARHYCHEVEPGAEALHAQVERLVQQAGNQADASVALYYFNASLYLLRVLKGNTTKRYQDGQKLEGADIKSEPKDSEVQTTSCLDLDFVTRVYSASLESLLTKRNSPLTIPMFLDLFSRYPVICKNLLPIVVQHVAGSSRPRHQAQACLLLQKALSARELRVCFEDPEWEQLISQVLGKTTQTLQTLGEAQSKGEHQRELSILELLNTVFRIVNHEKLSVDLTAFLGMLQGKQQKLQQNLQQGNHSSGSSRLYDLYWQAMNLLGVQRPKSEKKNVKDIPSDSQSPISTKRKKKGFLPETKKRKKLKSEGTTSEKKAASQQDAVTEGAMPAATGKDQPPSTGKKRRKRVKANTPSQVNGVTVAKSPAPNNPTLSPSTPPAKTPKVQKKKEKLSQVNGSTPVSPVEPESKKHQKALSTKEVKRRSSQSALPKKRARLSLVSRSPSLLQSGIRKRRVARRRVQTP

MYBBP1A

Myb-binding protein 1A

1328 amino acids

May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309).

Belongs to the MYBBP1A family.

148.855 kDa

MESRDPAQPMSPGEATQSGARPADRYGLLKHSREFLDFFWDIAKPEQETRLAATEKLLEYLRGRPKGSEMKYALKRLITGLGVGRETARPCYSLALAQLLQSFEDLPLCSILQQIQEKYDLHQVKKAMLRPALFANLFGVLALFQSGRLVKDQEALMKSVKLLQALAQYQNHLQEQPRKALVDILSEVSKATLQEILPEVLKADLNIILSSPEQLELFLLAQQKVPSKLKKLVGSVNLFSDENVPRLVNVLKMAASSVKKDRKLPAIALDLLRLALKEDKFPRFWKEVVEQGLLKMQFWPASYLCFRLLGAALPLLTKEQLHLVMQGDVIRHYGEHVCTAKLPKQFKFAPEMDDYVGTFLEGCQDDPERQLAVLVAFSSVTNQGLPVTPTFWRVVRFLSPPALQGYVAWLRAMFLQPDLDSLVDFSTNNQKKAQDSSLHMPERAVFRLRKWIIFRLVSIVDSLHLEMEEALTEQVARFCLFHSFFVTKKPTSQIPETKHPFSFPLENQAREAVSSAFFSLLQTLSTQFKQAPGQTQGGQPWTYHLVQFADLLLNHSHNVTTVTPFTAQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLLLVGIHLLKSPAESCDLLGDIQTCIRKSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLAQPSHLMRQVARSVFGHICSHLTPRALQLILDVLNPETSEDENDRVVVTDDSDERRLKGAEDKSEEGEDNRSSESEEESEGEESEEEERDGDVDQGFREQLMTVLQAGKALGGEDSENEEELGDEAMMALDQSLASLFAEQKLRIQARRDEKNKLQKEKALRRDFQIRVLDLVEVLVTKQPENALVLELLEPLLSIIRRSLRSSSSKQEQDLLHKTARIFTHHLCRARRYCHDLGERAGALHAQVERLVQQAGRQPDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPSHMPTGPQAASCLDLNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHITGPVRPRHQACLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENLRVLGEAQTKAQHQQALSSLELLNVLFRTCKHEKLTLDLTVLLGVLQGQQQSLQQGAHSTGSSRLHDLYWQAMKTLGVQRPKLEKKDAKEIPSATQSPISKKRKKKGFLPETKKRKKRKSEDGTPAEDGTPAATGGSQPPSMGRKKRNRTKAKVPAQANGTPTTKSPAPGAPTRSPSTPAKSPKLQKKNQKPSQVNGAPGSPTEPAGQKQHQKALPKKGVLGKSPLSALARKKARLSLVIRSPSLLQSGAKKKAQVRKAGKP

mybbp1a

Myb-binding protein 1A-like protein

1269 amino acids

May activate or repress transcription via interactions with sequence specific DNA-binding proteins. May play a role in the repression of the circadian clock gene expression.

Belongs to the MYBBP1A family.

144.011 kDa

MVAVMQTDMGETENSAVRPKVTDAKGILKQNRQFLDYFWDIAKPDRQIRLKAIEDLINYLKNSEQADELKYTLKRLVDGLSHTREDARSGYSVALAQLLSVFEEISLKSTLNSVKEKHNLLTASKKLIRNAVFGNFFGVLALSQSTRLHKEPQVMLECVQLLQSLSEYREHLRDLPRKTMVDILSETSQDVFEEVLFSALQSDLTSALKSPEQLELLLVALQKFPSVLKPKKLKKLLGTTAVITKQNMPRLVEVLKTAARSVKKENILPAVALDLLQVSLREDNFEMFWTDAIITGMMSEMPGPTHYLSFRLLGASLPLLSIPQLQFVLSGDVMRQYGEHTMSAQMPDRFKFAPEMAGYVGEFMQSCTDPDKQLVVVLGFTQLTNQGNPVVPSYWKALENMHPSAVQRYVDWLIEAFCKPQLENCLDFSTRRQKGNQEAAVESESCVSRFRKWIIPRLTFIVENQQIKKQEALVMKVVRFIFFHAFFEVKKPTSEIPETTQALSVPINQQTRTAVVSGFYSLLQALNSMMVLGESVEVQGLNFRRIVGVQADGSMWIYSVFQFASMLLNQNKYVKSLQSFSPEQRQGWDSVLESVEALRKKAKTASSPEHTAFQQLFLLIGIQMFTSPEESLDLLKDLQTCMEKAQAKKSKKKKATDEPHWVEVIVEILLSLVSQPSRLVRSVCKTVFGRICPHLTQAALSSILNVLDPNKDEDESGVVVTDDKKRKLKEEDEDDDDEEEDDDNDEGDDDDDDDDEEEGGEEGEESSDSSDDEEEDEAMEEGQEVDQNFRLELMKVLQGQNALATEEDGSDDEELDDAAMMKLDGSLASLFLEQRKKIQAKKDEKDRLNKEKGLVRDFKIKVLDMVEVFLSKQGFSPLVLGMVEPLLSVIENGMSSESSQPEQDYLRRVADIFRNRLCRGKFYCKEIDGREAELHEMLERLIGRAQKLTDSSVALYYFSAALYVLKVLRGSVVDQELSTMGKVEVERATTCLKNALTSFMTKRKSPLTGAMFIDLFHRFPVLCVNLMDTALENITAGLRDHQQGQACFIMLKALQCKHVKNLMTGEQTTELYKKVVDQLTKSLENVQCKNKTAHDKVVKALELCLHVVKIVLNQKMRVNLELLQDVLASMNAEGCLEKTGKLEDTYWSVMRLFGVIKPKMEKVKKVPEAEQTEETTKKKKGFLPETKKRKNRKKPTILEGKETETPVEKTPEGASGEGKKNKNKKKNKKRKQQAGEETQDQPTPKKAKMQQQQQQKQKKKKKKKGADGE

Mybbp1A

Myb-binding protein 1A

1133 amino acids

Has a role in rRNA biogenesis, cell proliferation and tissue growth by contributing to the localization of nclb to the nucleolus.

Belongs to the MYBBP1A family.

127.867 kDa

MKSKVDKPVTNGAPNATKTKAKEDRKRAKTQKSEADSQIPAKILKKSKKEKPAETEEKENTASNANLKVSQINKAVFVVFKKMQGSQLTKKMINSLITLLRDDTNAEQRTATTGYVLKRLIRSTGADDMKTVSLAASYIHCILNAVPAIDAFEVLETLKRDLAVGSQQRGKEDSLAAVGQLVTAFCILQTPQFAKAEPKLVTAVFQILAAQLKGREYLVSLCGDILAVSFKQLPAAIFEEYVWPLLQPELNKPLSGLKVNTCDVLLAVHLTFSSVLGRENILASLWPKKPVYTQLFDLYFSGSTIHSDGVYARLASFLVNGGKDMLAAWQQYIDSKQPLKLNAAKACAIQVLSHVLLNFKPREEQLILDIFTPTCVQFLLHECSSVKWDKGEGKKPSLKKLKEICFKFEGSLVLCYEKQFQNDDNKLHLLLKLLEHTLQLDSVISLPRFCQKLINQLSVESLHKLYDYYNNKLYSLEDEDRVSRVHCLNQMQLILNHSKLSQTAKWRQKQLNYLLLAGLFHLDASKKPCEAAQASAFSRQCAARCEEIFLGSLLHKCSGLPGLCQLLQKTLSYLNKELGQPDAESKLRSPRDESLQKAWKQVEKLLERPSKESDVVGQSFEALILFVSLALCTKIPPSITVLEDLIICRKNALQKSKEQVNEELKWQDVLTDALLQLLLQTGHFWREFVQLVATALIPHLEHGNLEQVLEVLNMNKNPLSKKSDGEEESDDELDKEESLKDSSDDSEDEDEDEEEDEGEDDAESHLAQIRESVRQALVNDGDADDDGASSVDWNDVDEEQGERLNAALERSFQMFRPKSRKAQEKERPTKSERIDSTNLLHFRIRALDLLELFITKKPTQSVILDVLHCVFQVYSHCAADSKLQSLREASLKLLKKILARNIELKENQSTAPILEAIEQLMSSGEEHSEEDQENGKQPASRQAKRDIIIWRDRCFAYLVSQASADGEPKKSAVWPLLVEFLELWVAKRRSRLSLASFEALFQSGQWQGVAPLAVVLASHLDVQKTRSFRRAQILKLLSEQGRRLEVAFKDNNSSSKKFEKQIARYVNQLETKASSSKELNLLLKILAQGGEKWQKLREQIQLVAKDLQPNKKVAKQKKQAAAKPMVVEDEEST