Protein
Modification methylase MwoI
Organism
Methanothermobacter wolfeii
Function
Recognizes the double-stranded DNA sequence GCNNNNNNNGC, causes specific methylation on N-4 on both strands, and protects the DNA from cleavage by the MwoI endonuclease.
Similarity
Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.
Sequence
MVKGKILFGDVFSALRCLEDNSISVALTSPPYWRQRDYGFKGQIGREKTPEEYIGRLIVIFRELRAKLKDDGVFFLNIGDKYKNRYGKSHLLQIPYRLAAHMIKDGWKLLDIIIWYKPNHMPSSVKDRFTNTYEPVLVFGKSDENIYTKKHPVLKIPLQQTKWKHTAVFPEKLVSSLLSRCNLKDGDYILDPFAGTGTTGAVVKKMKYQLYPKDLNVILIEKGKKFLDIITERTGIKEIKELKSSEYTWEPVNDKLAFSEDKPLIIIEDTHGETFIAKNSEEFSRIIMGMLSEEFQDFHREDAVYFFGVKNWKLSDLVLPGLLIDHGFILRNMIIIEDGSSWYPVFMLVKDTTRVNYKFYIDRIRKKPKTVLPEKWNQEDFIGLIVNDNLSKKPRKGEVVDIISTYSQDNFPKIVAVSWEDDNISLELCLNPRKDEFIMESLQFTCPHCGTQLIDTYDPLGDNICYNCQKEIYGKNSLPILKESKEIIESLESVENGEYQVGENIKPQYQKRCKESKSKFAGMERMNWGASPGARKTIIGDSFSKMRLYRLDQPTIARYLNIYMKKNDLRIKDITQALPPEYKHTVGHWFRKDFGGSIPLPEDVTLLEEILKLDKEFARILKRSVLKLQTVKHSLKGKNPGDFLELEENKLKEYLTKTYMPPSYYIKK