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mus-51

Gene
mus-51
Protein
ATP-dependent DNA helicase II subunit 1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
645 amino acids
Function
Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).
Similarity
Belongs to the ku70 family.
Mass
72.353 kDa
Sequence
MSWRKDQDERLDGDEGDEELDENDYKTQKDAVLFAIDVSKSMLKPPQNTGDKKADKDSALTAALTCAYQIMQQRIISQPKDMMGVLLFGTEKSKFRDDSGNGTGYPHCYLLSDLDIPGAEDVKKLKALIEDGDDEDEIMVPSKEPVIMSNMLFCANQVFTTNAANFGSRRLFIVTDNDDPHAGDKQAKSSAAVRAKDLYDLGVVIELFPISREDKKFDLSKFYDDIIYRNPAAEAGQSESPKTSKSGDGLTLLNSLISNINSKQTPKRSYFSNLPFELAPGLTISIKGYMPLNRQTPTRSCYVYEGEEQAQVVQSETAQVDFAARTVEKSELRKGYKFGGEHICFKPEELAELKQMGKKTLRIIGFKKRSKIPSWASVKKSIFIFPSEEQYVGSTRVFSALWQKLLKDDKVGIAWFVARENAHPVMVAIFPSGNPDDEEANTPYLPAGLWLYPLPFADDVRSVDHVTAPPRPADELTDQMRQVIQNLQLPKAMYDPRKYPNPSLQWHYKILQAKALDEETPDAMDDVTLPKYRQIDKRVGGYLAEWKEMLAKKANDLQNTRAFKREFEEDDERPAKRAKPSKKAASGGGGPANSNADLKKAFEQGTLGKMTVAELKDIMASKGISTAGRKAELVERLEQWVEENL