About Products Protein Database Contact

mus-21

Gene
mus-21
Protein
Serine/threonine-protein kinase tel1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
2939 amino acids
Function
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).
Similarity
Belongs to the PI3/PI4-kinase family. ATM subfamily.
Mass
328.696 kDa
Sequence
MAPATETVDFKKLIVTLNGKTITGRTSALKSLISYFKGDETGSQAESHSQKLFDDKTYHYVYEALFTCALTEKADYFSCLKSSKSDSVRNSCVKRLEGCAEALRLAVQHGAYKIKRKTATAIADHITQTLLDSDDNFFEPLLKGYVKVLSAFLNIQVNVENLAAFGGEKWESSIDLCLNAISRFLEAAEHDSGTSVRASPAPGTPATSRAGSVGPLSASVQVNGQLAIEFLACVKALTSASNAPVLRRAKRISQLVLRLLTLRHIKLGELQRDSFSILNNILVRVQTESIALTNTITTALVPVLSHCWQPRSLSRDAMSTSLKDEMLKTLYGIHLYLESLLREATDDKLLQDTEDLLDSLWSEYSRRDDKTRLQLGDVTFSAMQLHPDHPLTMVFGLRPYHLAGEQNWALLENIALLEIVYAKNSQRDRQHLEDEPDKPRKRRRVIGSSNRIHQKLMSQDPAVQLTALQLIPFLSALKHPSLEEVKGALVDLSQFISAKQGLVASWAMIACSSLAAHKTSRDPSLSAMWKQAWHIGIRSLSLPSTSRSACVLLNWILKAKLLSDHEIAGDVNQIITTADISGPAMLVDSAPVLMLTLLRIRNAIFPNASQSTSSHVIRWVFLKWNPCESAYASVHGVHAAPVDLINLLRACYEMPPLRMNTSLTVFDGPVAQFRAVQKQRHAMLRYLLLLEDEAPPEDSHKATSTDQPKREEIRAADSSSSHSAKRLILELLFPKLDELLQMVELWHKRGESDSAAPVSTDRLVSVASTCIVGAFIMPELVGLNSSMSRDLEKTVFGIVEGMIKAIAESPQSEDFFNLVLEVSAPYIPTLGEAELTHFKREEPYALRLFATVSNSLLEKTRRESPTDSDPASMDLDDEFDSQETRKSTTAGKRFLSRRDITLKHTPEAFYLDTSLRLHLLRIIRADDGELGRVPDPIVDHLLELSDEDLLSCRLFMQELFASDVVTPVDLAIRMIERIAATISNNQYTCCEAAMCTVMDIMEGFITMWTDEELEISNLVGDIYDHLIKRALPNNSLSSTAQIWFSRLLFRLLEVNPMFASQVLKLPSTRSTLLTILRDAPMDVKFFIGINLPRIFGMHVLQTHDDIIVEILEVLPGEGMEGIAFRLFVLAELACKWPTLLRRCAYHIFETPGKNQTSASHATSCLKRVSRCLNLSSPQELFTIFAPQILYTWLAIDSIDEIPYSIFGFSNLAELLSKSQSEAVGIMIMRGHETDARELAKTLKLSIQELVTQNFSKIVAYSIAQDSSLPNEVTGESRVRRIIGAEPYSSNIILNFADILAIFFEICDQEYPIEDSFRKDAANFAYAADIMDKIKAFGHLDTMLPPNQQPSYKAKFLKRQILHLVKRTNYELHDIWTPALVVFVARKLLNTIHPALGPLHACSVLRKIRVLICLAGDTALYGYPLEMLLHSLRAFVVDPECADDALGITQYLITEGSDHLIRFPSFLAGYALSCLADLRVFLESSQSSTTQESQFKATKSKAQLFHAWFSKYLANYTTNAWKDKTQKEAFEAITQSAANIRVMGNAEKGTHESKLLLEILKDWGRQHQLLNGPARSVALSILCGSFNVPPPSRLDVIQSDEEALAHGAAVWMSCGSKKLSSEYLAWAGRVIGRSYAASGDVPPELLRESRLQEYRKKSPVNFDFMESEEALLSLIEALTASSDGFRAGLAEAALRVAVSDALHENDRPLITACQKSLSESLLVASEWGELRIPRSDRFSVEHPNETEIFSAEFLESPEWAQQLTTLLAQSVPGSVALRVLPPILTKVKGFAEQAFPFIVHNVLEYELDQTQGMKQKLSEALKEWLTSTSPAARDNQKLLINTILYLRTQANPNETSIADRLHWLEVNFSIAAAAATRCGMYKVALLFAELASTEITRQSRRSSAIQGLGDTSEILLDIFENIDDPDAYYGLTQDASLSTVLARLEYENDGTKSLAFRGAQYDSHLRRRDVASQQDGQALIKALSSLGLAGLSNSLLQTQQSLDGSSTSLDSTFITARRLEIWNLPAPAATENWAVTVYKAYQSMHQASDINMVRSAVHDGLTKTLKHLTGKSLNTLTLRHQLGALATLAELDDVLNTGDLSELNGIIEDFQARSKWMMSGQYDDVSRILSCRETTLSLWSQRHNLRPARLTPANARLAQIRGMLVSSDIYRFHRATQETLNLSTTLTDLIRPSEQMGLAVDAAIRMETANSLWDQGEMISSIRMLQNIDKESPLEKQTVPVSRSDLLSKIGYQVSVARLESPDTIQKNYLEPALKELKGKSEGKEAGRVYHQFAMFCDEQLQNPDGLEDLARLQNLERGKNDEVTQLKALIASTRDSQLKNKYSSHLSKAKQWLDLDQQELRRVEQTRSEFVRLSLQNYLLSLAASDEYNNDALRFTALWLECSEDDMVNEVVKRYLSKVPTRKFAPLINQLSSRLQHQEGLFQITLIGLVYSICLDHPYHGMYQIWSGVKARSIKNDEVALSRQKATDKIARAIKKSGASAAKIYLAINATSKVYHNLAMDRDAKKYKAGHKMNIKDSKAGLEFLAAFAEFPIPPPTMQMPLLASCDYSQVPMIVKFEPQMSIASGVSAPKIITAIGSDGRQYKQLVKGGNDDLRQDAIMEQVFAAVSELLKHHRATRQRNLGIRTYKVLPLTETTGVIEFVSNTIPLHEYLMPAHEIYYPKDLKGSHCRKEIMNAQSKSVDTRVAVYRKVTERFHPVMRYFFMEWFPDPDEWFARRTAYTRTTAAISMLGHVLGLGDRHGHNILLDTKTGEVVHIDLGVAFELGRILPVPELVPFRLTRDIVDGMGITKTEGVFRRCCEFTLDALREETYSIMTILDVLRYDPLYSWSMSPLRMARLQNVRVGAGEDDVVEAEDERRAGDKKSTKNLNEPSEADRALEVVRKKLSKTLSVMATVNDLINQATDERNLAVLFCGWAAYA