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murU

Gene
murU
Protein
N-acetylmuramate alpha-1-phosphate uridylyltransferase
Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15)
Length
242 amino acids
Function
Catalyzes the formation of UDP-N-acetylmuramate (UDP-MurNAc), a crucial precursor of the bacterial peptidoglycan cell wall, from UTP and MurNAc-alpha-1P. Is likely involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc (PubMed:23831760). Is able to complement the fosfomycin sensitivity phenotype of a P.putida mutant lacking murU (PubMed:23831760).
Similarity
Belongs to the nucleotidyltransferase MurU family.
Mass
25.59 kDa
Sequence
MSQAPKIAMVLAAGLGTRMRPLTNDRPKALVEVAGKALIDHMLDRLVAASVETAVVNVHYFADLVEAHLRAREAKGLAPRIVISDERVQALETGGGIKHALALLGEGPVFVANIDSIWIEHAGAAVDAVAAAWDPERMDVCLMLASTTESLGFHDTGDVFLSADGLVRFKDAGEIAPLVYVGVHICKPEITADGPDGPFSLLPLWKRLAADGRVCGVAPEGLWMHVGDPQAKLAAEARLAEA

Gene
murU
Protein
N-acetylmuramate alpha-1-phosphate uridylyltransferase
Organism
Neisseria meningitidis serogroup B (strain MC58)
Length
231 amino acids
Function
Catalyzes the formation of UDP-N-acetylmuramate (UDP-MurNAc), a crucial precursor of the bacterial peptidoglycan cell wall, from UTP and MurNAc-alpha-1P. Is likely involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc (PubMed:23831760). Is able to complement the fosfomycin sensitivity phenotype of a P.putida mutant lacking murU (PubMed:23831760).
Similarity
Belongs to the nucleotidyltransferase MurU family.
Mass
24.537 kDa
Sequence
MKAMILAAGRGERMRPLTDTTPKPLLDVAGKPLIGWHLCRLKQAGFTEIVINHAWLGRQIEDALGDGSAYGVNIAYSPEPAGGLETAGGIAQALPLLGGQPFLVVNGDVLTDIDFTAAFQTASSLPEHISAHLWLVENPPHNPDGDFSLLPDSSVRPEVNGGNGLTFSGVGIYRPEMFDGIEAGSVAKLAPVLRGEMRQNRVSGQKHTGLWLDVGTVCRLKEAQALAGAWK

Gene
murU
Protein
N-acetylmuramate alpha-1-phosphate uridylyltransferase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
224 amino acids
Function
Catalyzes the formation of UDP-N-acetylmuramate (UDP-MurNAc), a crucial precursor of the bacterial peptidoglycan cell wall, from UTP and MurNAc-alpha-1P (By similarity). Is involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc (PubMed:24819062). Plays a role in intrinsic resistance to fosfomycin, which targets the de novo synthesis of UDP-MurNAc (PubMed:24819062).
Similarity
Belongs to the nucleotidyltransferase MurU family.
Mass
24.149 kDa
Sequence
MKAMILAAGRGERMRPTTLHTPKPLIEAAGVPLIERQLLALRQAGVDDWVINHAWLGEQIEAYLGDGSRLGGRIAYSPEGEPLETGGGIFRALPLLGEQPFLLLNGDVWSDFDYSRLHLADGDLAHLVLVDNPAHHPAGDFHLDAGGRVGETREAGGNLTYSGIAVLHPALFEGCQPGAFKLAPLLRKAIAAGRVSGEHHRGQWVDVGTHERLAEVERLLAEHA

Gene
murU
Protein
N-acetylmuramate alpha-1-phosphate uridylyltransferase
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Length
223 amino acids
Function
Catalyzes the formation of UDP-N-acetylmuramate (UDP-MurNAc), a crucial precursor of the bacterial peptidoglycan cell wall, from UTP and MurNAc-alpha-1P (PubMed:23831760, PubMed:25767118). Is involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc (PubMed:23831760). Plays a role in intrinsic resistance to fosfomycin, which targets the de novo synthesis of UDP-MurNAc (PubMed:23831760). Is not able to use GlcNAc-alpha-1P and GalNAc-alpha-1P as substrates (PubMed:23831760). Cannot accept other nucleotide triphosphates (ATP, CTP, TTP, or GTP) than UTP (PubMed:25767118).
Similarity
Belongs to the nucleotidyltransferase MurU family.
Mass
23.814 kDa
Sequence
MKAMILAAGKGERMRPLTLHTPKPLVPVAGQPLIEYHLRALAAAGVTEVVINHAWLGQQIEDHLGDGSRFGLSIRYSPEGEPLETGGGIFKALPLLGDAPFLLVNGDVWTDYDFARLQAPLQGLAHLVLVDNPGHHGRGDFRLVGEQVVDGDDAPGTLTFSGISVLHPALFEGCQAGAFKLAPLLRQAMAAGKVSGEHYRGHWVDVGTLERLAEAESLIGERA