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mtnP

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
326 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
35.319 kDa
Sequence
MGMIISMAMTAVTIWTKTKPGRVSCFIRKNSTMVNAPIGIIGGSGLYQMEALKNVEEVTLDTPFGAPSDSFIVGELAGVRVAFLARHGRGHHLLPSEIPFRANIHGMKQLGVKYLISASAVGSLQAEAKPLDMVVPDQFIDRTRQRISTFFGEGIVAHIGFGNPICPQLAQCLSTAIAGLELEGVTLHDRGTYVSMEGPAFSTIAESNLYRSWGGTVIGMTNLPEAKLAREAEIAYATLALVTDYDCWHPDHDHVTVEMVIGNLQKNAVNAQQVILETVKQLAANPFESIAHRALQYAVLTPPDKFPAATYEKLSLLLGKYYPPAP

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Synechocystis sp. (strain PCC 6803 / GT-S)
Length
326 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
35.319 kDa
Sequence
MGMIISMAMTAVTIWTKTKPGRVSCFIRKNSTMVNAPIGIIGGSGLYQMEALKNVEEVTLDTPFGAPSDSFIVGELAGVRVAFLARHGRGHHLLPSEIPFRANIHGMKQLGVKYLISASAVGSLQAEAKPLDMVVPDQFIDRTRQRISTFFGEGIVAHIGFGNPICPQLAQCLSTAIAGLELEGVTLHDRGTYVSMEGPAFSTIAESNLYRSWGGTVIGMTNLPEAKLAREAEIAYATLALVTDYDCWHPDHDHVTVEMVIGNLQKNAVNAQQVILETVKQLAANPFESIAHRALQYAVLTPPDKFPAATYEKLSLLLGKYYPPAP

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Length
314 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
35.041 kDa
Sequence
MINKHFSSEEIEQDGKSCLLKNARLGVLGGSGLYSIDSIENIKELDIETPYGKPSDSLRIGNLGGMEVVFLARHGRHHIYTPTEIPYRANIWALRSLNVRWILSPSAVGSLQEQVRPLDMVVPDQFIDRTHQRPLTFFCDGAVAHVTMADPFCPTLSRLLAEEGELLMPEARQVHKGGTYLAMEGPAFSTRAESQLYRSWGCKVIGMTNHTEARLAREAEIAYTSLSMVTDYDCWHEGFGNVSVDLVIENLAANAKLASKIVEATAKRISKLLPPSEAHTALKNSLMTSKDKVSETTREKINLFTENYWGKFNK

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
Length
299 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
32.753 kDa
Sequence
MSYPQARIGVIGGSGLYQMADLADTVEVQFNTPFGPPSDALVIGTLAGERVAFLPRHGRGHRLLPAELPFQANIYAMKMLGVEYLLSASAVGSLREEYRPRDIVFPDQFFDRTKDRPSTFFGGGLVAHIGFDQPICTELAHLAAEAARGVELIGETRIHTGGTYVCMEGPAFSTLAESRLYRSWGMDIIGMTNLQEAKLAREAEICYATMALVTDYDCWHPDHGAVTVELIIDNLHKNAENAQRIVRAVVERLHAAAPPCASHSALKYALLTQPEDVPQATKQKLAAILAKYPAYRPEV

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Length
294 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
32.078 kDa
Sequence
MSEAYRQPVLGVIGGSGVYDIDGLEGARWQTVESPFGDVSDQILRGTLDGLEMAFLPRHGRGHVLAPSDVNYRANIDALKRAGVTEILSVSAVGSLAEDLPPGTFVIADQFIDRTFAREKSFFGKGLVAHVSMAHPVSAWLGDRVEEVLADLAIPHRRGGTYLCMEGPQFSTLAESNLYRQWGCHVIGMTNMPEAKLAREAEIAYCTVAMVTDFDCWHPDHDHVSVEAVVRVLLQNADKARSLVKAMPAKLKDRPYPLPDGSHRSLDNAIITHPDRRNPGMARKLSAVAGRVLG

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Koribacter versatilis (strain Ellin345)
Length
292 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
31.561 kDa
Sequence
MQAEIGIIGGSGLYSMPGVSDVQEVRVTTPFGEPSDPYVLGTLAGRKVAFLARHGRGHRLLPTELNFRANIHGFKQLGVERIISVSAVGSLKEEHRPLEFVIPDQFYDRTKQRVSTFFGEGIVAHVGFGDPVCGEMAKVVKHATDKAGVVAKAGGTYVCMEGPQFSTKAESNLYRSWGFDVIGMTNLQEAKLAREAELCYVTVAMVTDYDCWHPDHDAVTVDQIVAVLLKNAENACSVVREAVAAMPKDRTCKCGSALATAIITNKDVVPAATKEKLKLIIGKYFGEQKAGA

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Length
291 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
31.461 kDa
Sequence
MTQAVLGIIGGSGIYDLPGLEGAHEEVIKSPWGEPSAPLRRGTIAGLPIVFLPRHDKGHRLSPSDINYRANIDVLKRAGVTDLISLSACGSFKEEMPPGTFVLVDQFVDRTHKRESSFFGRGCVAHVSMAHPVSPRLRIHLAAAAEAEGIAIARGGTYVCMEGPQFSTYAESMTYKTSGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLTSNADKAKALVARLAKDFPREHEPCPIGSDRALDTALITAPEARDPELLKKLDAVAGRVLRG

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Length
290 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
30.95 kDa
Sequence
MKTMIGVIGGSGVYEIDGLEDAVWTKVETPWGDPSDEILTGRLDGVPMAFLPRHGRGHVHSPTTVPYRANIDALKRLGVTDLVSVSACGSFREEMAPGDFVIVDQFIDRSFARAKSFFGSGCVAHVSLAHPTCGRLSALCAEAARATGVTVHEGGTYLCMEGPQFSTLAESLLYKSWGCHVIGMTNMPEAKLAREAEICYASVAMVTDYDSWHPHHGEVDITAIIATLGTNADHARGLVAGLPARLGTERDLCPHGCDRALDHALMTAPAKRDPELLAKLDAVAGRVLKG

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Thermosynechococcus elongatus (strain BP-1)
Length
289 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
31.354 kDa
Sequence
MTAKIGIIGGSGLYKMEALTDVEEVRLTTPFGDPSDAFICGKIGGVPVVFLARHGRHHHLLPTEIPFRANIYGFKSLGVEYLLSASAVGSLQEAVKPLDIVVPDQFIDRTRNRISTFFGDGIVAHIGFADPVCPALAGVLADAIADLNLPDVTLHRQGTYVCMEGPAFSTLAESNLYRSWGGTVIGMTNLPEAKLAREAEIAYATLALVTDYDCWHPEHDSVTVEMIMGNLQRNVKNAQAIICETVKRVHAHPPVSKAHRALKNAILTPLDQVPAATKEKLHLLLAKYL

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Length
288 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
31.271 kDa
Sequence
MHSATIGVIGGSGLYAMPDLKNPEEVRLTTPFGDPSDAFIIGELEGRRVAFLPRHGRGHRLNPSEVPARANIYAFKLLGVRALISVSAVGSLREDYAPGHAVIPDQIFDRTKGIRPATFFEGGVVAHVAFDRPFCPYLSNILLHAAQAAGAVVHQGGTLVVMEGPQFSTKAESEENRRRGHSLIGMTALPEAKLAREAEIAYATLAMVTDYDVWHPEHDAVTAEQVIKVLSANVNLSQQIVRHAVAQIDENFTSPAHDALRYAIVTHPDHIPAAVKERLAPIAGRYWS

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Length
287 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
32.069 kDa
Sequence
MSYNVRVAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGHFLSPPEVPNHANICALKQLGVEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYFGNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLVCMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKLLSELIHVLGNGDDLSLKNSTRYSIITAPEKRNPETVKKLRVLFPEYF

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Length
287 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
32.031 kDa
Sequence
MSYNVRAAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGHFLSPPEVPNHANICALKQLGVEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYFGNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLVCMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKLLSELIHVLGNGDDLSLKNSTRYSIITAPEKRNSETVKKLRVLFPEYF

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Length
286 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
31.105 kDa
Sequence
MEQVIGVIGGSGLYEMEGLQDVRSIVVETPFGAPSDEFVTGVLDGVRMVFLPRHGRGHRLLPTEVNYRANIYGMKKLGVTRIISVSAVGSMREEIVPGHIVIPDQFIDRTNATRANTFFGNGVVAHIQFADPVCADLSADLYAAAQEAGATVHRGGTYICMEGPAFSTRAESNLYRSFGVSVIGMTNIPEAKLAREAEICYGVIALATDYDCWHESHDDVSVDAIIAIIKQNVAMAKSIIRNAVRRIDRERNCPCASALRYAIITDKAAIPAETKERLDLIIGSYV

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Length
279 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
31.014 kDa
Sequence
MVKLTNPPKSPKELGFDEFPSIGIIGGSGLYDPGIFENAVEVQIHTPYGLPSDNVIVGRVAGRVVAFLPRHGRGHKYPPHKIPYRANIYSLYMLGVRSIVAVSAVGSLRPDYAPGDFVVPDQFVDMTKGREYTFYDGPRTCHIQIGLEPFTQEIRQILIETAKKYNRTHDGGCYVCIEGPRFSTKAESRIWREVFGCDIIGMTLVPEINLARELGMCYGLIALVTDYDIWVPHQPVTAEAVEKMMTEKLGIIKKVIAEAVPKLPAELPKCSETLKYACV

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Length
275 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
30.737 kDa
Sequence
MFEITRPPGVRAHVGVIGGSGLYDPGIVENPVEVKVSTPYGNPSDFIVVGDVAGVKVAFLPRHGRGHRIPPHAINYRANIWALKALGVKWVISVSAVGSLREDYRPGDFVVPDQFIDMTKNRRHYTFYDGPVTVHVSMADPFCEDLRQRLIDSGRRLGYTVHERGTYVCIEGPRFSTRAESRVWKDVFKADIIGMTLVPEINLACEAQLCYATLAMVTDYDVWADRPVTAEEVERVMISNVERARRMLYDVIPKLAGEPELERCSCCRALDTAAI

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Length
274 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
30.784 kDa
Sequence
MPDFPPKPSVKADIAIIGGSGLYDPGVLENAKEYKIYTPYGEPSDYIIVGELGGKRVAFLPRHGRGHRIPPHKINYRANIWALKMLGVKWVIAVSAVGSLREDYKPGDIVVPDQFIDMTKSRVYTFFDEGIVAHVSMADPFCEHLRQEIISTARELGYRVHPRGTYICIEGPRFSTRAESRVWREVFKADIIGMTLVPEVNLACEAQLCYATIALVTDYDVWAERPVTAEEVARVMKENTEKAKKILYKLIPRLPPEPDKARCSCCSSLETALL

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
270 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
30.141 kDa
Sequence
MIEQNEKASIGIIGGSGLYDPGIFSESKEIKVYTPYGQPSDFITIGKIGNKSVAFLPRHGRGHRIPPHKINYRANIWALKELGVRWVISVSAVGSLRMDYKLGDFVIPDQFIDMTKNREYSFFDGPVVAHVSMADPFCNSLRKLAIETAKELNIKTHESGTYICIEGPRFSTRAESRTWREVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAKKLLYALIQKLPEKPEEGSCSCCNSLKTALV

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
264 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Prefers MTA, with 2% activity on adenosine, 0.8% activity on S-adenosyl-L-homocysteine and no activity on other tested nucleosides.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
27.964 kDa
Sequence
MHNNGRMLGVIGGSGFYTFFGSDTRTVNSDTPYGQPSAPITIGTIGVHDVAFLPRHGAHHQYSAHAVPYRANMWALRALGVRRVFGPCAVGSLDPELEPGAVVVPDQLVDRTSGRADTYFDFGGVHAAFADPYCPTLRAAVTGLPGVVDGGTMVVIQGPRFSTRAESQWFAAAGCNLVNMTGYPEAVLARELELCYAAIALVTDVDAGVAAGDGVKAADVFAAFGENIELLKRLVRAAIDRVADERTCTHCQHHAGVPLPFELP

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Nitrosopumilus maritimus (strain SCM1)
Length
263 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
29.043 kDa
Sequence
MEKDVEIGIFGGTGIYDSGLLEDAKEVDIDTPYGKPSDTITVGTFKGRKIAFLPRHGKKHTIPPHMINFKANIWAFKELGVTRIIAPSAVGSLKEELAPGHFVLPTQFLDFTKSRDGSFSEDGRVIHISVADPFCPELQSSITEVTDSLDMNIHKDCTYVCIEGPRFSTKAESKFYRTTGADIIGMTLVPECQLAREAQICYASISTVTDYDVWAEKPVTAKEVLETLSKNVEGTKKILTELIEKIPKDRSCSCAKALEEAEF

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Thermofilum pendens (strain DSM 2475 / Hrk 5)
Length
262 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
29.467 kDa
Sequence
MEKVKIGIIGGSGLYSPDFLTNPKEEKIYTPYGPPSSHVVIGEIAGRKVAFIPRHGKRHEIPPHKVNYRANIYALKELGVERLISVSAVGSLREDYKPGDFVCTDQFIDMTKGRVYTFYDGPVVAHVSMADPFCPELRELCIRSARKLGITMHEKGTYICIEGPRFSTRAESRLWRQFGADIIGMTLVPEVNLAREARMCFLNIAMVTDYDVWAEKPVTAHEVARVMAENTEKVKRLLADLIPSIPEERKCQCARALDEALI

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Length
261 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
29.364 kDa
Sequence
MTVNMAYIGIIGGSGLYDLMPESTKKVIETPFGNPSDAVEIGEVNGVEVAFLPRHGKKHTIPPHKVNYRANIWALHELGVERIIGLNAVGSLREDYKPGEIVIPDQYIDFTKRRDLTFYDGPQVYHISEADPFCPEMNSILYDTARNLKIPVHNSGTYITIEGPRFSTRAESKMFRQFADIIGMTLVPEVSLAGELALCYSVIASITDYDVWSTKPVDAREVMNIMKQNDHKVRDILFNALPLIKKERKCSCSLRLDNAKM

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
259 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
27.723 kDa
Sequence
MMLGVIGGSGFYTFFGSDARAVSVETPYGPPSAPITVGTVGDHEVAFLPRHGVKHEFSPHTVPYRANLWALRSLGVRRVFAPCAVGSLTPDLGPGSIVVPDQLVDRTSGRDDTYFDSGGIHVAFADPYCPTLRAAATGLPGVVDGGTMVVIQGPRFSTRAESRWFASQGFTLVNMTGYPEAVLARELEMCYAAVALVTDLDAGIEVGSGVRAVDVFAEFERNMPPFKKLVFEALEAVEVERTCTHCLTHSGVQLPFELP

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
257 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
29.22 kDa
Sequence
MPKIGIIGGSGVYGIFEPKETVKVHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHEVPYRANIWALHELGVERVIAVNAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPRVAHISMADPFCPELRRIFIETAKELNLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAEKPVDAQEVLRVMKENEEKVQKLLKRAIPKIPEERKCGCADVLKTMFV

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Length
257 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
29.175 kDa
Sequence
MPKIGIIGGSGVYGVFEPKEVVKVHTPYGRPSAPIEIGEIEGVEVAFIPRHGKYHEFPPHQVPYRANIWALHELGVERVIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKVAHVSMADPFCPELRKIFIETAKELNLPVHERGTYVCIEGPRFSTRAESRMFRQFADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAEKPVDAQEVLRVMKENEEKVQKLLKRAIPKIPEERKCGCADVLKTMFV

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Length
257 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
29.076 kDa
Sequence
MPRIGIIGGSGVYGVFEPKETVKVHTPYGRPSAPVEIGEIEGVEVAFIPRHGKHHEFPPHEVPYRANIWALKELGVERVIGITAVGSLREEYKPGDIVITDQFIDFTKKRDYTFYNGPRVAHVSMADPFCPEMRKIFYETAKELGFPVHEKGTYVCIEGPRFSTRAESFMFRQFAHIIGMTLVPEVNLARELGMCYVNIATVTDYDVWADKPVDAQEVLKVMAENNYKVQELLKKGIPKIPEERHCGCADVLKTMFV

Gene
mtnP
Protein
Probable S-methyl-5'-thioinosine phosphorylase
Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Length
248 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
26.809 kDa
Sequence
MQTIALAVIGGTGVYTLSQFDDVQVYEVETLYGRPSGPIRVGMLFGQRVAFFARHGEEHALPPHKINYRANIAALQQLGVSRVLALNTVGGINEAFGPRTLVCPDQLIDYTWGRVSTFCEEVGSEVLHVDFGHPYSPLLRGCLLRAARDVDVSLVEYGCYGVTQGPRLETIAEIDRLRRDGCDLVGMTGMPEAALAREKGLEYACLGIVSNWAAGCGDGAEITMGEILSNVATAFSCLPELISKVARE

Gene
mtnP
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Cenarchaeum symbiosum (strain A)
Length
240 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
25.982 kDa
Sequence
MLDNAEELSMDTPYGAPSDTITLGGIGGRRLAFIPRHGKKHNIAPHKINYRANIWALQKLGVSRVVAPSAVGSLREELAPGRFVVPSQFLDFTRTREGSFSEDGRVIHISVAEPFCPELRTVLLDAAGDAHDGGTYACIEGPRFSTRAESALFRAAGADIIGMTMVPECQLSREAQMCYASVSTVTDYDAWAEKAVTAKEVLATLADNVERTKALLAKLIPTIPRDRKCTCADALAEAEF