Mtmr12

Myotubularin-related protein 12

748 amino acids

Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

85.686 kDa

MLGKGGVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEEVTLHLLPGEQLLCEASTVLKYVQEDSCQLGICGRLVCTDFRISFLGDEGSAVDNGAETHFKNKIIGVNDIPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKEEEVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVHGTAADPRNCTVMFDTPKDWCWELERTKGSVKYKTVSVNEGYRVCDRLPAYFVVPTPLLEDDVKRFQGRGIPIWCWSCHNGSALLKMSALPKEQDDSALQIQKSFLDGIYKTIHRPPYEMVKTEDLSSNFLSLQEIQSSYCKFKQLFLIDSSSEFWDTDVKWFSLLESSGWLDIIRRCLKRAIEIIECLEAQNMNVLLLEENASDLCCLLSSLVQVMMDAHCRTWTGFQSLIQKEWVMGGHSFLDRCNHLHQSDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRESLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDKGQRKGSRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDDLQDNSREFYDNWHSKPTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGRVATMGKLLEMMEEVQSLQEKIEARHHRQEAIHVQAPGLLRNSARLSSLFPFAMHQRHSAKPVLPTSGWKALGGEDDLAKREDEFVDLGDV

MTMR12

Myotubularin-related protein 12

747 amino acids

Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity).

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

86.148 kDa

MLGKGVVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLKYVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGVFDEKKKTLFGQLKKYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGIYKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLKNPLYVEKPKLDKGQRKGMRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVATLSKLLEMMEEVQSLQEKIDERHHSQQAPQAEAPCLLRNSARLSSLFPFALLQRHSSKPVLPTSGWKALGDEDDLAKREDEFVDLGDV

Mtmr12

Myotubularin-related protein 12

747 amino acids

Acts as an adapter for the myotubularin-related phosphatases (PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (PubMed:23818870).

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

85.516 kDa

MLGKGGVGGGGGTKAPKPSFVSYVRPEEIHTDEKEVTEKEVTLHLLPGEQLLCEASTVLKYVQEDSCQRGVYGRLVCTDFKISFLGDEDSALDNGGEAQFKNKIIGVNDVPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKEEEVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVHGTATDSRNCTVMFDTPKDWCWELERTKGSVKYRTVSVNEGYRVSDRLPAYFVVPTPLPEDDVRRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGALQVQKSFLDGIYKTIHRPPYEMVKTEDLSSNFLSLQEIQSAYCKFKQLFLIDNSSEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECLEAQNVNVLLLEENASDLCCLLSSLVQVMMDAHCRTRTGFQSLIQKEWVMGGHSFLDRCNHLHQSDKEEVPIFLLFLDCVWQLVHQYPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRENLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDRGQQKGSRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDDLQDSSREFYDSWHSKPTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGRVATMGKLLEMMEEVQSLQEKIEARHHRQEAVHAEAPGLLRNSVRLSSLFPFALLQRHSAKPVLPTSGWKALGGEDDLAKREDEFVDLGDV

MTMR12

Myotubularin-related protein 12

747 amino acids

Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

85.946 kDa

MLGKGVVGGGGGTKGPKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLKYVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGVFDEKKKTLFGQLKKYPGKLIIHCKDFRVFQFCLGYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGIYKTIHRSPYEIVKTEDVSSNFLSLQEIQTAYSKFKQLFLTDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDANMGREGQDAQSKPLNLLTVWDWSVQFEPKAQTLLKNPLYVEKPKLDKGQRKGMRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVATMSKLLEMMEEVQSLQEKIDERHHSQQVPQAEAPCLLRNSARLSSLFPFALLQRHSSKPVLPTSGWKALGDEDDLAKREDEFVDLGDV

mtmr12

Myotubularin-related protein 12

736 amino acids

Acts as an adapter for the myotubularin phosphatase mtm1 to regulate mtm1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing mtm1 protein levels, required for skeletal muscle maintenance but not for myogenesis (PubMed:23818870). In skeletal muscle cells, does not regulate mtm1 subcellular localization (PubMed:23818870).

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

84.796 kDa

MLSLGSGGAKSSKPSFVSYVTPEEIKLEKDPQKKEKHPDLLPGEVVFCSANPILKYTQDDLSQRGVFGTLLCTNFRVAFISDDAPQEEMSKTFKNKLYGENDIPLMCVDHIYGVYDEKRKLITGGLVKNKCPSKMIIHCKDLRVFQFCLTFSKEEDAKRIFQGIAHHCLEEKSLKCVFAFSYLRSTNPEMLRKREAIMFDSPEDWTQEMKRTKAQCRLVTENENFELSQRLPQYFVIPSALGDLFNYQGKGLPIWCWSHHSGCALFKASFPSMTQEDGDFQSHLDTMITAVARNYLYSVKTEDLSESLPTLQDIQQSYNKFKQYFLIDNTTDFWLSDVKWFSSLESSGWLDIIRQCLQKAVEVVECLEKDNTNVLITEEEGTDLCCVISSLAQIMLDPYYRTLMGFQSLVQKEWVAGCHAFLDRCNHLHQKDKECHSPVFLLFLECVWQLVQQHSPAFQFSETYLTVLSDSVHVPIFSTFLFNSAHHRESVMKAESPIAQSRPLSCPTVWDWSVQFDSKAQNFFFNPLYSEKVKHERTVRRPHKHKHQRQLSLPSSAFKTPTKKGFFKDETDSLKKMLRVKRISRWMGSPDSPVVASREFYESWQQRPLDYHGLLLPSLDGPSVRIWMQRYLRWIPEVHIMGGGSVAIMTKLMELLSQVEDLKRVLEQRDPSLATQPDHPPPLHHRLPSFGSSGRLSSSFPFTYSRNRSFKPIIPTGLMQSLMVADNLANQEDETS