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mtm-6

Gene
mtm-6
Protein
Myotubularin-related protein 6
Organism
Caenorhabditis elegans
Length
676 amino acids
Function
May dephosphorylate phosphatidylinositol-3-phosphate (PI3P) (PubMed:12788949, PubMed:14565969). In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels (PubMed:14565969, PubMed:21076391). Regulates fluid phase endocytosis in coelomocytes (PubMed:14565969). Controls the endosomal localization of sorting nexin snx-3 and the levels of sorting receptor mig-14 (PubMed:21076391). By regulating the retrograde transport of mig-14, may be involved in the secretion of Wnt ligands such as egl-20 (PubMed:21076391). Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast descendants and HSN neurons during larval development (PubMed:21076391). Involved in the formation of correct synapse number in DA9 motor neurons probably in part by regulating the secretion of Wnt ligand egl-20 (PubMed:25479419).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
77.309 kDa
Sequence
MRFEDIGISKVDKVCLVDRLGCQENLVGTVHVTTTHIIFRAENGSKELWLATGLISSVEKGTLTAAGCMLVIRCKHFQVITLLISRDKSCQDLYETLQRAAKPVSVNVTELLAFENREPVEDVRGWRRLDWNSEMTRQGITKSQWTESNINEGYTICDTYPNKLWFPTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLTGFSARCVEDEKLMELVGKANTNSDNLFLVDTRPRVNAMVNKVQGKGFEDERNYSNMRFHFFDIENIHVMRASQARLLDAVTKCRDVTEYWKTLEASGWLKHVRSVVECSLFLAESISRGTSCVVHCSDGWDRTSQVVALCQLLLDPYYRTIHGFQVLIEKDWLGFGHKFDDRCGHVGALNDEAGKEVSPIFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDLNLSKRTKSLWTWMDARHDDYMNPFYSPTAHVALLDLDTRAARFTVWTAMYNRFDNGLQPRERLEDLTMAAMEHVGVLESHVAQLRTRLAELKTQQNQQITSTNTPTNMVDSGMSSATDDLKNLSLSHPLDPLSSTLPILERATSQESGVMDSSLYYPDEALTKYSLKWQPLRGADRCSNPACRGEFSSTIERRIHCHLCGMIFCRRCLKVSADERERVCDKCKTD