mtm-3

Myotubularin-related protein 3

1006 amino acids

Preferentially dephosphorylates phosphatidylinositol 3-phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P) (PubMed:18393358, PubMed:25124690). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation (PubMed:25124690). Thought to have a role in maintenance of muscle function (PubMed:18393358). Involved in locomotion and lifespan determination (PubMed:18393358).

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

113.614 kDa

MTVTSSAAIDIGGGGGGRRSDRLDSDRTSEDMSFIASPANESFQIGASFVDVQNESSGSIDTATATLHELNYTFGMPPVTEESENMPQNYETVVELLPGEERAPINKLTEFPIEGGSLFVTNFRIVVILKDKEVEEALRFLVFPLQDIEQIDLAIPAFIHLSLKIGRMFTICFKTAEDAALVHKILYTAFQRLNRPISSIYTSRPQDWTSKNTDNPMQSLNAFAWKFSEAVDELDRDGKLPSWLLRADSVAQEITHIDFNRLGMSEHFQISSVNENFEVCPTYPEKIIVPKGITDDDIRKGAPYRSIGRFPAVIWRCRKTRAVLMRSSQPQVGILSWRNPTDEKIIEEAVKASRIEGEEKKQFIIMDARGYTSAFANRARSGGFENTEYYQQAKLEFLGLPNIHAVRGSFNNVRTMLHNLGPNEQLLTSLQTTGWLLNLSNLLVNAANCADHLSKGHSVLVHCSDGWDRTTQVTTLAKIMLDEYYRTVKGFEELIRRDWIAFGHKLYDRQLVAFGNWGTSDERSPVFLQFLEAVRHLQREQPTLFQFTHAYLIKLAKHAYSGLFGSFLFNSHKERREAMEKCKGTLVDIWRFIGPHNEEYVNQSFDEHYTGAVKPVNVSVINLRVWHEVFADEEEHYTQIFSPKEERPLSGCTTPMNTSTSTNLVKSKSSESINSLNVDGSAKESSQQHPTCSTTPSDNTNSLPMSTSFIQQSLYQPKVRGVAAIDRDGVIRFEDDEQAMLRKKNKLRAEEIRRKDEKIEELRRRAVLDTNKVSPGQRQSYSESDVETTGTLERVMSDVSMVDPVNELPHFKPNTTWEGESGHCAYCKKEFNKLSVYVEDRQHHCRNCGRVVCEDCSKNRFSVIEEGKSVQKRACDSCYDSMHETDLKLSSSSTTTTSSSTKIENDSNVPGLDNNSDNVSENVSENAIPDIIVEEKEAEDPIKEAESPSKETKCPKTLRNFISFSPKSSMRKNKVHSRDPLKSIDEGSSSQQAESDDVLDVNEQPL