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mtm-1

Gene
mtm-1
Protein
Myotubularin-related protein 1
Organism
Caenorhabditis elegans
Length
588 amino acids
Function
Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles (PubMed:19816564, PubMed:21490059). Negatively regulates phagocytosis of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex (PubMed:19816564, PubMed:21490059). In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane (PubMed:21490059). Essential for embryonic and larval development (PubMed:19816564). May promote migration of distal tip cells (PubMed:19816564).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Mass
67.593 kDa
Sequence
MDDRGNNSGEVGEFASSSMIQESIDLKLLAAESLIWTEKNVTYFGPLGKFPGKIVITRYRMVFLVGDGGKMYEQWKLDIPLGQVSRIEKVGRKTTSVAKRGDDNYGFTIYCKDYRVYRFTCNPASSDRKNVCDSLNRYAFPLSHNLPMFASVHAAETPRLMKDGWKIYSAEKEYERLGIPNSRLWKEVDINKDYKFSETYPRTFVIPTVSWEEGKPFVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISGKRSAEDERHLTNIMNANANCRELLILDARPAVNAKLNKAKGGGYEENYVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSILEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDNYSDGERSPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFLYNSEKIRLKDKKCDETTISFWSYVLENKKKFRNPMFKHGKSNKVINVNPSLCGLHVWIDYYARSNPYVVTPNHEDVQQPGAQFVDEKKQLLDEIMALDDAAQKLTA