msy1

Mechanosensitive ion channel protein Msy1

1011 amino acids

Regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock. Acts as a mechanosensitive calcium channel in response to membrane stretch. The conductance is about 0.25 nanosiemens (PubMed:22910366). Involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock (PubMed:25041276).

Belongs to the MscS (TC 1.A.23) family.

114.27 kDa

MSSPTSPTSSPGRHHWSNSKDGMPPEYTNQDPNSDQADNENSDAKAHQPQHSPQHSTENQGHTGTSDTSSLEMELSKLHPESKQRQLPHSPEHERSRSPIASVVSYRSHMTLEDENQIFNAEMAVRGSQSLQRRPTGRSVRGSMRRLSSHRSKSMRTSKSKKSGDYERTAENEEAAQEAENHLDNFGVVTFGTEAPIKAPDHPVTIFGRIFKFIQQRSFYLRSLIYIIPLGVLLLIPVFIGRFYHPQPPYRDELGHEYERHLHVGGVDLMWMAIWWEIIWLSIWAARYAAKVIPYFFAFFVSFISNNVTKWRCMAVALEFPITLFLWMLAVYVSFLPIMTRRHIGDYGVPDHVRVKLPWQQSANNVLITLFITSIMNLVEKVLMQLIAMSLHRREYESRILYNKFAINELARLYGYARQRSFDFKDAIHRAQADVFKFADHQHGKKRAAAARVAQNALNKTTYKAISAFNFATDMVNKVAGEITNREVEKSSSPKSVVLHLLKTTRGCQSLARCLFEALVNPENPDLVLDDFIPVYTDETGEVDNATLEACYSIFDRDLNGDITCEEIELACVEIGKERKSISASLRDLNDSISKLDGICMFIVAVITLFIFLYLIARNFSGVLTSAGTTLLGLSWLFSGSAQELLSSIIFVFVKHPYDVGDRVDVMINGTVTSAMVKEISIMSTEFRLLTGKVIQAPNSLLNTLWILNMRRSDGIADPVTVNLKFGTTLQQIEQLRIKIIDFLKEEKRDYKPDLLTEVTDLPDLYSMSLCVVFFHKYNFQDEVLRMRRRNMFMCALMTYMQELDIVSPIFNSPGKSKDSPMYVNFNNGSMEGVKLSGGNDGGGTENHRDSTVGGGILKNPKAYPYREPTPPGSSDSDTASVSKKRVDFSLGTRHLMPAFDDVADIGSKRLGRDSLPDAVIENAGTEAMRREAEERRRAEEEEYERSQQESSSNEENENASRTSGARFSFSSKASRLSARPSARTVPPLQHISIQDLREPNENNTSKSARL

MSY1

Tyrosine--tRNA ligase, mitochondrial

492 amino acids

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Belongs to the class-I aminoacyl-tRNA synthetase family.

55.287 kDa

MLELRSCSNLVNSSRRLVPLVTYSGLSAITLPKSRFYSQPSALEVQGTSDSRSDNILDELKQRGLVSQVSQPESFLRTKLNGNDKIKLYCGVDPTAQSLHLGNLVPLMVLLHFYVKGHDIVTVIGGATGKVGDPSGRKTERDVMENDIRQSNVASISQQLQRFFKNGLEYYRNRCALTEDVPSGKYTPRNNFNWWKDIKMLDFLADFGRHIRVQSMLARDSISSRLQTKNGLGFNEFTYQVLQAYDFYHLYKEENVTIQVGGNDQWGNITAGIDLINRIQPIKNKGLPFGITVPLLTTATGEKFGKSAGNAVFIDPSINTAYDVYQFFYNTLDADVPKFLKIFTFLNSSEIKKIVETHIKSPSLRYGQTLLAKEVTDMLYGVGSGSDSEALSNIIFGRYDGTLSAAKLVDLCKKARILQYADREIDLIKLICKLVNCSVSEARRKLSQGSVYLHHSKSKVNENISNLAPFLIDDRVLILRIGKQKCFIIEMR

msy1

Tyrosine--tRNA ligase, mitochondrial

445 amino acids

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Belongs to the class-I aminoacyl-tRNA synthetase family.

49.498 kDa

MSRLLACLKQLQARSLIHNTTLLQPSCNVNSVYLGADPTAASLHVGNLVALMPLVHFFLNGFPVFTVIGDATAQLGDPSGRSTSRKQMAETTRTANSNSIHNQLKDLSSSILSYAQDCNYPFSQMPSSSQWSIVRNSSWYENLKLLKFLSSVGPHVRVSQMLARDSVTTRLQSPSGLSFAELTYQLLQAYDYSYLYENHSVNLQIGGSDQWGNITAGTDLVRRTHPNANVYALTTPLLTSSSGQKLGKSAGNAIWLDPKLTDSYSLYQYFISAPDDLACKCLDMLTLLPLEQLEQIKAEHEKDPSQRIVHKYLASNVVRMVHGKKALELAQIQTKLLHGAHQAPFGFYSEAPQQGDSFPSLPEIRALFKDCKFYRTIDSSIKDQPFSRLLRTLQIYTSRKEATEHILSGAVSLGHKPILDSNYKFPDNSLFVLRAGKRTFVLDSL