Protein
Methanesulfonate monooxygenase hydroxylase subunit alpha
Organism
Methylosulfonomonas methylovora
Function
Methanesulfonate monooxygenase (MSAMO) mediates the primary degradation of methanesulfonic acid (MSA) to produce formaldehyd and inorganic sulfite by initial hydroxylation of the carbon atom prior to spontaneous cleavage of the unstable hydroxymethanesulfonic acid. MSAMO has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methane- to butanesulfonate) and excludes all larger molecules, such as arylsulfonates and aromatic sulfonates. All MSAMO components are required for enzyme activity.
Similarity
Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.
Sequence
MPARNHTQWMATPPLQKGEWVDSRVYTDQEIFDEELEKIFKKAWVPFRHESELPKAYDFRTTSIANEPIIVTRGPDNEVRAFLNVCPHRGMLIERRPSGSLYEGQPSGNPKRMTCMFHAWQFDMKGNCVYISREKEGYQDRLPKESVGLRRLRCEVKFGGFVWVNLDDNPISLEDWAGEPFQCLRKTLEAEPMEVFHYHKAIVDTNYKLWHDTNCEFYHDFMHYHNRVTGFNDAYFARKNESFEHGHILVGTFEVNYDQYEGFESRAGLSFPHLPPNQWYMIDLFPGMNFNLRGSALRCDVVTPLGPNKVMIEFRGLGLKSDTPEERQTRINHHNSIWGPFGRNLHEDLIGVQGQGTTMRPGQESRRILHGRQENQTIHDENGMRHYYDKWGKWMNRMPSNPELPYNAPAIAAE